The Use of Repetitive Magnetic Stimulation for Strength Training of the Quadriceps Muscle
Primary Purpose
Chronic Obstructive Pulmonary Disease
Status
Completed
Phase
Not Applicable
Locations
United Kingdom
Study Type
Interventional
Intervention
Repetitive magnetic stimulation to the quadriceps
Sponsored by
About this trial
This is an interventional treatment trial for Chronic Obstructive Pulmonary Disease focused on measuring Neuromuscular electrical stimulation
Eligibility Criteria
Inclusion Criteria: Chronic Obstructive Pulmonary Disease Exclusion Criteria: Aspirin therapy Cardiac Pacemaker -
Sites / Locations
- Royal Brompton Hospital
Outcomes
Primary Outcome Measures
Quadriceps Twitch force
Secondary Outcome Measures
Quadriceps maximal voluntary contraction, Oxidative enzyme profile, fibre type distribution and capillarity of the muscle, quality of life questionnaires
Full Information
NCT ID
NCT00159367
First Posted
September 9, 2005
Last Updated
September 27, 2023
Sponsor
Imperial College London
Collaborators
Magstim Company, Whitland, Wales
1. Study Identification
Unique Protocol Identification Number
NCT00159367
Brief Title
The Use of Repetitive Magnetic Stimulation for Strength Training of the Quadriceps Muscle
Official Title
The Use of Repetitive Magnetic Stimulation for Strength Training of the Quadriceps Muscle in Patients With Chronic Obstructive Pulmonary Disease
Study Type
Interventional
2. Study Status
Record Verification Date
September 2023
Overall Recruitment Status
Completed
Study Start Date
January 2005 (undefined)
Primary Completion Date
February 2006 (Actual)
Study Completion Date
February 2006 (Actual)
3. Sponsor/Collaborators
Name of the Sponsor
Imperial College London
Collaborators
Magstim Company, Whitland, Wales
4. Oversight
5. Study Description
Brief Summary
We intend to use repetitive magnetic stimulation to the quadriceps muscle to try to improve strength and improve the metabolic function of the muscle.
Detailed Description
Quadriceps strength is reduced in COPD. Increasing quadriceps strength is one of the goals of pulmonary rehabilitation yet some patients with severe COPD are unable to exercise with sufficient intensity, due to breathlessness, to achieve a true training benefit.
Transcutaneous electrical stimulation of the femoral nerve has been shown to improve quadriceps muscle strength, muscle mass, and performance in patients with severe COPD. Magnetic stimulation may be preferred because it offers the opportunity to train the whole muscle and because it is painless. In this pilot study we are investigating whether repetitive magnetic stimulation camn increase the strength of the quadriceps muscle and whether it confers any change in structure or metabolism of the muscle itself.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Chronic Obstructive Pulmonary Disease
Keywords
Neuromuscular electrical stimulation
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
20 (Anticipated)
8. Arms, Groups, and Interventions
Intervention Type
Device
Intervention Name(s)
Repetitive magnetic stimulation to the quadriceps
Primary Outcome Measure Information:
Title
Quadriceps Twitch force
Secondary Outcome Measure Information:
Title
Quadriceps maximal voluntary contraction, Oxidative enzyme profile, fibre type distribution and capillarity of the muscle, quality of life questionnaires
10. Eligibility
Sex
All
Minimum Age & Unit of Time
40 Years
Maximum Age & Unit of Time
85 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Chronic Obstructive Pulmonary Disease
Exclusion Criteria:
Aspirin therapy Cardiac Pacemaker
-
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Michael I Polkey, PhD
Organizational Affiliation
Imperial College London
Official's Role
Principal Investigator
Facility Information:
Facility Name
Royal Brompton Hospital
City
London
ZIP/Postal Code
Sw3 6NP
Country
United Kingdom
12. IPD Sharing Statement
Learn more about this trial
The Use of Repetitive Magnetic Stimulation for Strength Training of the Quadriceps Muscle
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