Treatments for Psychogenic Nonepileptic Seizures (NES) (NES)
Convulsion, Non-Epileptic, Conversion Disorder, Depression
About this trial
This is an interventional treatment trial for Convulsion, Non-Epileptic focused on measuring nonepileptic seizure, pseudoseizure, conversion disorder, psychogenic, Depression, Anxiety, Abuse, post-traumatic stress disorder, sertraline, serotonin, randomized controlled trial
Eligibility Criteria
Inclusion Criteria: Video electroencephalogram (vEEG) confirmed diagnosis of NES Have at least one nonepileptic seizure per month Comorbid diagnosis of either depression, anxiety, or post traumatic stress disorder (PTSD) Able to complete self report symptom scales Not receiving optimized antidepressant medication Exclusion Criteria: Equivocal electroencephalogram (EEG) findings Current suicidality, litigation, or self-mutilation Using monoamine oxidase inhibitors (MAOIs), pimozide, or sumatriptan Allergy/sensitivity to sertraline Current alcohol/drug dependence Serious medical illness requiring current hospitalization
Sites / Locations
- Rhode Island Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
sertraline
placebo
flexible dose sertraline, 25 to 200mg titration as tolerated, administered over 12 weeks with a two week untreated lead in period monitoring their baseline NES
flexible dose placebo, administered over 12 weeks with a two week untreated lead in period monitoring their baseline NES