Alzheimer's in Long-Term Care--Treatment for Agitation

Inclusion Criteria: No age limit probable/possible Alzheimer's disease diagnosis disruptive agitated behaviors (e.g., irritability, aggression, uncooperativeness, pacing) no hypotension no concurrent use of alpha-1-blockers no delirium, schizophrenia, mania, psychotic symptoms. Exclusion Criteria: Cardiovascular: unstable angina, recent myocardial infarction, second or third degree atrioventricular (AV) block, preexisting hypotension (systolic blood pressure less than 110) or orthostatic hypotension Other medical exclusions: chronic renal or hepatic failure, or any unstable medical condition Exclusionary medications: current treatment with prazosin, other alpha-1-blockers Current enrollment in a separate investigational drug trial Psychoactive medications: subjects may be psychoactive medication-free or be partial responders (by subjective assessment of referring health care professional) to one psychoactive medication from any of the following classes: antipsychotics, anticonvulsants, mood stabilizers, antidepressants, benzodiazepines, or buspirone. Partial response is defined as some improvement in agitated behavior but persistence of agitated behaviors severe enough to cause patient distress and/or difficulty with caregiving. Although not formally rated, this improvement is equivalent to a Clinical Global Impression of Change (CGIC) rating of no more than minimal improvement (improvement is noticed by not enough to improve patient function or caregiver's practical management of the patient). Psychiatric/behavioral: lifetime schizophrenia; current delirium, mania, depression, or uncontrolled persistent distressing psychotic symptoms (hallucinations, delusions), substance abuse, panic disorder, or any behavior which poses an immediate danger to patient or others or which results in the patient being too uncooperative to meet the requirements of study participation.