Intensive Chemo-Radiotherapy With Peripheral Blood Progenitor Cell Rescue for Children With Advanced Neuroblastoma and Sarcomas
Neuroblastoma, Ewings Sarcoma, Non-rhabdomyosarcoma Soft Tissue Sarcoma
About this trial
This is an interventional treatment trial for Neuroblastoma focused on measuring Stem cell transplant, High-risk pediatric tumors
Eligibility Criteria
Inclusion Criteria: Previously untreated neuroblastoma Stage D > 365 days Previously untreated neuroblastoma Stage C at age > 365 days with n-myc amplification Previously untreated metastatic Ewings sarcoma/PNET Previously untreated non-rhabdomyosarcoma soft tissue sarcoma Confirmation of neuroblastoma at time of diagnosis by histologic specimen or with bone marrow specimen showing solid tumor. Confirmation of sarcoma by histologic specimen with evidence of metastatic disease be imaging study Patient 19 years of age or younger ANC > 1000 Platelet count > 75,000 SGOT < 2.5 x ULN Normal serum creatinine levels for age Exclusion Criteria: Previous malignancy requiring nonsurgical treatment or bone marrow transplant. Relapsed disease
Sites / Locations
- Dana-Farber Cancer Institute