A Double-Blind Placebo Controlled Trial of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Negative Symptoms in Schizophrenia (rTMS)
Schizophrenia
About this trial
This is an interventional treatment trial for Schizophrenia focused on measuring Transcranial Magnetic Stimulation, Schizophrenia, Negative Symptoms
Eligibility Criteria
Inclusion Criteria: DSM-IV diagnosis of schizophrenia or schizoaffective disorder, age over 18 Persistent negative symptoms of moderate to severe intensity Failure to respond to a minimum of two antipsychotic medications No increase or initiation of new antipsychotic therapy in the four weeks prior to entering the trial Exclusion Criteria: Prominent positive symptoms Have an unstable medical condition, neurological disorder or any history of seizure disorder or are currently pregnant or lactating Previous brain injury or surgery, any metal clips, plates or other metal items in the head, cardiac pacemaker Subjects at high risk of violence or suicide as determined by the investigator and treating clinicians Substance dependence
Sites / Locations
- Alfred Psychiatry Research Centre
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Active Treatment
Sham rTMS
Bilateral high frequency (10 Hertz) rTMS
Bilateral Sham rTMS