Effectiveness of Clozapine Versus Olanzapine for Treatment-resistant Schizophrenia (COES)
Schizophrenia
About this trial
This is an interventional treatment trial for Schizophrenia focused on measuring Clozapine, olanzapine
Eligibility Criteria
Inclusion Criteria: Age 20-60 years; Diagnosis of treatment refractory schizophrenia or schizoaffective disorder; BPRS score > 21 (0-6) scale; Either two 6-8 week trials of typical neuroleptics given at a dosage of 600 mg/day of CPZ or its equivalent or one 6-8 week trial of an atypical antipsychotic at a reasonable dose (i.e. risperidone 4-6 mg/day); The patient (or the patient's authorized legal representative) must understand the nature of the study and sign the informed consent; Clinically appropriate for clozapine or olanzapine Exclusion Criteria: Current substance abuse; Suicide or homicide risk; Pregnancy or lactation; History of seizures or blood dyscrasias
Sites / Locations
- Commonwealth Research Center
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Clozapine
olanzapine
Clozapine or olanzapine in treatment resistant schizophrenia
clozapine or olanzapine in treatment resistant schizophrenia