Back to resultsClinical, Molecular and Metabolic Characteristics of Parkinson's Disease (PD) Patients With Parkin Mutation
Primary Purpose
Parkinson's Disease
Status
Unknown status
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
positron emission tomography
Sponsored by
About this trial
This is an interventional diagnostic trial for Parkinson's Disease focused on measuring Parkinson's disease, parkin mutation, Juvenile parkinson's disease, positron emission tomography
Eligibility Criteria
Inclusion Criteria: Juvenile Parkinson's disease (< 45 years) Parkin mutation Normal brain magnetic resonance imaging (MRI) Exclusion Criteria: Contraindication to brain MRI Women without effective contraception
Sites / Locations
- Centre d'Investigation Clinique-Hôpital Pitié-SalpetriereRecruiting
Outcomes
Primary Outcome Measures
Parkin mutation
Motor disability
Neuropsychological evaluation
Psychiatric evaluation
Secondary Outcome Measures
Positron emission tomography
Full Information
NCT ID
NCT00169364
First Posted
September 12, 2005
Last Updated
August 28, 2007
Sponsor
Groupe Hospitalier Pitie-Salpetriere
Collaborators
University Hospital, Tours
1. Study Identification
Unique Protocol Identification Number
NCT00169364
Brief Title
Clinical, Molecular and Metabolic Characteristics of Parkinson's Disease (PD) Patients With Parkin Mutation
Official Title
Comparison of Clinical, Molecular and Metabolic Characteristics of PD Patients With and Without Parkin Mutation
Study Type
Interventional
2. Study Status
Record Verification Date
September 2005
Overall Recruitment Status
Unknown status
Study Start Date
May 2002 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
undefined (undefined)
3. Sponsor/Collaborators
Name of the Sponsor
Groupe Hospitalier Pitie-Salpetriere
Collaborators
University Hospital, Tours
4. Oversight
5. Study Description
Brief Summary
Parkinson's disease is a frequent neurodegenerative disorder. Genetic forms of the disease have been recently identified. The monogenic form due to parkin mutation is responsible for many familial cases and sporadic forms. However, the relationship between the mutation and the genotype of patients is not fully established. The aim of this study is to compare clinical, metabolic and neuropsychological characteristics obtained in patients with parkin mutation with those of patients without parkin mutation.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Parkinson's Disease
Keywords
Parkinson's disease, parkin mutation, Juvenile parkinson's disease, positron emission tomography
7. Study Design
Primary Purpose
Diagnostic
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
50 (Anticipated)
8. Arms, Groups, and Interventions
Intervention Type
Device
Intervention Name(s)
positron emission tomography
Primary Outcome Measure Information:
Title
Parkin mutation
Title
Motor disability
Title
Neuropsychological evaluation
Title
Psychiatric evaluation
Secondary Outcome Measure Information:
Title
Positron emission tomography
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
80 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Juvenile Parkinson's disease (< 45 years)
Parkin mutation
Normal brain magnetic resonance imaging (MRI)
Exclusion Criteria:
Contraindication to brain MRI
Women without effective contraception
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Alexis Brice, MD, PhD
Phone
33-142162183
Email
brice@ccr.jussieu.fr
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Alexis Brice, MD, PhD
Organizational Affiliation
Groupe Hospitalier Pitié-Salpêtrière
Official's Role
Study Director
Facility Information:
Facility Name
Centre d'Investigation Clinique-Hôpital Pitié-Salpetriere
City
Paris
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marie-Laure Welter, MD
Phone
33-142161950
Email
marie-laure.welter@psl.aphp.fr
First Name & Middle Initial & Last Name & Degree
Alexis Brice, MD, PhD
12. IPD Sharing Statement
Learn more about this trial
Clinical, Molecular and Metabolic Characteristics of Parkinson's Disease (PD) Patients With Parkin Mutation
We'll reach out to this number within 24 hrs