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Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients?

Primary Purpose

Kidney Failure, Chronic

Status

Unknown status

Phase

Not Applicable

Locations

Taiwan

Study Type

Interventional

Intervention

vitamin C, intravenous injection

Sponsored by

National Taiwan University Hospital

About this trial

This is an interventional treatment trial for Kidney Failure, Chronic

Eligibility Criteria

20 Years - 80 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria: chronic hemodialysis patients Exclusion Criteria: allergic to vitamin C, using steroid, etc

Sites / Locations

National Taiwan University Hospital

Outcomes

Primary Outcome Measures

Skin pigmentation extent

Secondary Outcome Measures

blood anti-oxidant level

Full Information

NCT ID

First Posted

September 12, 2005

Last Updated

September 12, 2005

Sponsor

National Taiwan University Hospital

1. Study Identification

Unique Protocol Identification Number

NCT00172302

Brief Title

Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients?

Official Title

Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients?

Study Type

Interventional

2. Study Status

Record Verification Date

May 2005

Overall Recruitment Status

Unknown status

Study Start Date

November 2005 (undefined)

Primary Completion Date

undefined (undefined)

Study Completion Date

undefined (undefined)

3. Sponsor/Collaborators

Name of the Sponsor

National Taiwan University Hospital

4. Oversight

5. Study Description

Brief Summary

Intravenous vitamin C may improve skin hyperpigmentation in chronic hemodialysis patients

Detailed Description

Melanogenesis is caused by enzymatic conversion of tyrosine to melanin pigments.Ascorbic acid has the ability to inhibit peroxidase and may thus inhibit melanin synthesis.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Kidney Failure, Chronic

7. Study Design

Primary Purpose

Treatment

Study Phase

Not Applicable

Interventional Study Model

Crossover Assignment

Masking

Double

Allocation

Randomized

Enrollment

40 (false)

8. Arms, Groups, and Interventions

Intervention Type

Drug

Intervention Name(s)

vitamin C, intravenous injection

Primary Outcome Measure Information:

Title

Skin pigmentation extent

Secondary Outcome Measure Information:

Title

blood anti-oxidant level

10. Eligibility

Sex

All

Minimum Age & Unit of Time

20 Years

Maximum Age & Unit of Time

80 Years

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria: chronic hemodialysis patients Exclusion Criteria: allergic to vitamin C, using steroid, etc

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Kao Tze-Wah, MD

Organizational Affiliation

National Taiwan University Hospital

Official's Role

Principal Investigator

Facility Information:

Facility Name

National Taiwan University Hospital

City

Taipei

ZIP/Postal Code

100

Country

Taiwan

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Tze-Wah Kao, MD

Phone

886-2-2356-2000

Email

twkao@ha.mc.ntu.edu.tw

First Name & Middle Initial & Last Name & Degree

Tze-Wah Kao, MD

12. IPD Sharing Statement

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Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients?

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