Vancomycin Study: Treatment of Catheter Related Bloodstream Infection Caused by Coagulase Negative Staphylococcus
Staphylococcal Infections
About this trial
This is an interventional treatment trial for Staphylococcal Infections focused on measuring Vancomycin, Coagulase Negative Staphylococcus, Central Venous Catheter, Bloodstream infection, CNS bloodstream infection
Eligibility Criteria
Inclusion Criteria: Patients admitted to the ICU who require treatment for suspected or documented intravascular device associated (IVDA) bacteremia due to coagulase-negative staphylococci (CNS). Suspected IVDA bacteremia due to CNS is defined as finding of gram positive cocci in blood in a patient with either an intravascular device (IVD) in situ or within 24 hours of catheter removal, with clinical signs of sepsis: two signs of systemic inflammatory response syndrome (SIRS): heart rate (HR) > 90, Temp > 38 or < 36, white blood cell (WBC) > 12 or < 4, respiratory rate (RR) > 20 or pCO2 < 32; and with no obvious source of bacteremia other than the IVD. Exclusion Criteria: Underlying valvular heart disease Prosthetic valve or graft A history of infectious endocarditis Bone marrow transplant recipient Neutropenia (< 0.5 X 10^9/L) Solid organ transplant recipient Known hypersensitivity to vancomycin Calculated creatinine clearance < 25 ml/min
Sites / Locations
- Vancouver General Hospital Intensive Care Unit