Alfuzosin Hydrochloride to Promote Passage of Distal Ureteral Calculi
Kidney Calculi, Ureteral Calculi, Colic
About this trial
This is an interventional treatment trial for Kidney Calculi
Eligibility Criteria
Inclusion Criteria: Age =>18 <8mm ureteral calculus below the pelvic brim identified by non-contrast CT scan and/or intravenous pyelogram Exclusion Criteria: Subject with know hypersensitivity to Alfuzosin hydrochloride or any component of Alfuzosin hydrochloride tablets Pregnant/Nursing females Solitary kidney Renal insufficiency (Creatinine>1.8) Urinary infection (fever >101, positive urine culture, many bacteria on urinalysis) Moderate or severe hepatic insufficiency (Childs-Pugh categories B and C) Potent CYP3A4 inhibitors such as ketoconazole, itraconazole, and ritonavir, since Alfuzosin blood levels are increased Other alpha-blockers Phosphodiesterase type 5 inhibitors for erectile dysfunction Any subject for whom the principal investigator feels it would not be in his or her best interest to participate in the study
Sites / Locations
- University of Minnesota
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Alfuzosin
Placebo