Improving Symptoms of Schizophrenia and Schizoaffective Disorder by Supplementing Medications With Pravastatin

Inclusion Criteria: Diagnosis of schizophrenia or schizoaffective disorder Male and female subjects; age 18-65 years inclusive Ability to provide informed consent No psychiatric hospitalization in the last 30 days prior to randomization PANSS score at study entry between 80 and 120 inclusive, OR those who continue to experience some residual positive and/or negative symptoms and are not at their baseline level of functioning. Current psychiatric medications stable for at least 30 days Currently receiving only one antipsychotic medication Female subjects of child-bearing age must use an acceptable method of birth control Exclusion Criteria: Active, uncontrolled, or chronic liver disease Heart failure Current alcohol abuse or dependence Female subjects who are pregnant, lactating or plan to become pregnant during the study period History of allergic reaction with any statin in the past Kidney disorder or other evidence of renal dysfunction Uncontrolled diabetes Untreated hyperlipidemia Concurrently receiving treatment with cyclosporine, gemfibrozil, clofibrate, fenofibrate, niacin, macrolide antibiotics, erythromycin, HIV protease inhibitors, nefazodone, or verapamil