Efficacy of Metronidazole Versus Metronidazole and Rifampin in CDAD Treatment
Clostridium Enterocolitis, Antibiotic-Associated Diarrhea, Pseudomembranous Colitis
About this trial
This is an interventional treatment trial for Clostridium Enterocolitis focused on measuring Antibiotic associated diarrhea, C. difficile, Metronidazole, Rifampin
Eligibility Criteria
Inclusion Criteria: Inpatients + outpatients diagnosed with CDAD based on SHEA definition [Laboratory confirmation for presence of C.difficile toxin using enzyme immunoassay and no other etiology for diarrhea + Presence of 1 or more of the following: diarrhea (6 watery stool over 36 hours or 3 unformed stools in 24 hours for at least 2days), pseudomembranes at endoscopy]. Exclusion Criteria: Age < 14 yr Known hypersensitivity to metronidazole, rifampin Receiving medication(s) with potential significant drug interaction with rifampin Active liver disease as indicated by ALT > 200 U/L Adynamic ileus Toxic megacolon Pregnancy
Sites / Locations
- Hamilton General Hospital
- McMaster University Medical Centre
- St. Joseph's Healthcare
- Henderson General Hospital