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Treatment of Suicidal Women With Borderline Personality Disorder

Primary Purpose

Borderline Personality Disorder, Suicide

Status
Completed
Phase
Phase 2
Locations
United States
Study Type
Interventional
Intervention
Standard dialectical behavior therapy (SDBT)
Individual DBT with no DBT group sessions (DBT-I)
Group Skills DBT with no DBT individual sessions (DBT-S)
Sponsored by
University of Washington
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Borderline Personality Disorder focused on measuring Suicide, Women, Emotions, Psychotherapy, Group

Eligibility Criteria

18 Years - 60 Years (Adult)FemaleDoes not accept healthy volunteers

Inclusion Criteria: Diagnosis of BPD At least one suicide attempt in the year prior to study entry AND at least one intentional self-injury within the 8 weeks prior to study entry Willing and able to comply with all study requirements Exclusion Criteria: IQ less than 70 Life-threatening anorexia Street homelessness with no contact information Admittance to a hospital with no expectation of discharge within 3 weeks prior to study entry OR sentenced to a jail or prison term that will last for more than 3 weeks Ordered by the court to receive psychological treatment Meet DSM-IV criteria for schizophrenia, bipolar disorder, or seizure disorder Medical conditions other than BPD that may interfere with the study

Sites / Locations

  • University of Washington, Department of Psychology, Behavior Research and Therapy Clinics

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Active Comparator

Active Comparator

Arm Label

S-DBT

DBT-I

DBT-S

Arm Description

Participants receive standard dialectical behavior therapy

Participants receive individual dialectical behavior therapy plus activities group

Participants receive dialectical behavior therapy group skills plus case management

Outcomes

Primary Outcome Measures

Suicidal thoughts or attempts

Secondary Outcome Measures

Coping skills

Full Information

First Posted
September 13, 2005
Last Updated
January 31, 2012
Sponsor
University of Washington
Collaborators
National Institute of Mental Health (NIMH)
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1. Study Identification

Unique Protocol Identification Number
NCT00183651
Brief Title
Treatment of Suicidal Women With Borderline Personality Disorder
Official Title
Assessment and Treatment of Parasuicidal Patients
Study Type
Interventional

2. Study Status

Record Verification Date
January 2012
Overall Recruitment Status
Completed
Study Start Date
April 2004 (undefined)
Primary Completion Date
September 2008 (Actual)
Study Completion Date
June 2010 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Washington
Collaborators
National Institute of Mental Health (NIMH)

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
This study is a component analysis of dialectical behavior therapy (DBT) to determine the importance of DBT skills training and DBT individual therapy in treating suicidal women with borderline personality disorder.
Detailed Description
People with borderline personality disorder have limited behavioral skills and react abnormally to emotional stimulation. Standard dialectical behavior therapy (SDBT) has been shown to be an effective treatment for borderline personality disorder. This treatment combines weekly group sessions, at which patients learn new ways of dealing with their emotions, with weekly individual sessions with a therapist to discuss their emotions. The study compares SDBT to both individual DBT with no skills training and DBT skills training with no individual therapy. The study will determine whether efficacy of standard DBT is reduced when either DBT skills training or individual DBT therapy is removed. Participants are randomly assigned to receive 1 year of SDBT, DBT with group sessions but no individual sessions, and DBT with individual sessions with no group sessions. Participants are monitored for 1 year after completing their assigned therapy. Throughout the 1-year study and during the 1-year follow-up period, self-report scales and questionnaires are used to assess participants every 4 months. These scales and questionnaires measure participants' suicidal thoughts and attempts, treatment compliance, emotional coping skills, social functioning, and overall well-being.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Borderline Personality Disorder, Suicide
Keywords
Suicide, Women, Emotions, Psychotherapy, Group

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 2
Interventional Study Model
Parallel Assignment
Masking
Outcomes Assessor
Allocation
Randomized
Enrollment
99 (Actual)

8. Arms, Groups, and Interventions

Arm Title
S-DBT
Arm Type
Experimental
Arm Description
Participants receive standard dialectical behavior therapy
Arm Title
DBT-I
Arm Type
Active Comparator
Arm Description
Participants receive individual dialectical behavior therapy plus activities group
Arm Title
DBT-S
Arm Type
Active Comparator
Arm Description
Participants receive dialectical behavior therapy group skills plus case management
Intervention Type
Behavioral
Intervention Name(s)
Standard dialectical behavior therapy (SDBT)
Other Intervention Name(s)
DBT, SDBT
Intervention Description
Standard DBT includes: 1) individual DBT therapy (1 hour per week), 2) DBT group skills training (2.5 hours per week), 3) telephone consultation (as needed), and 4) therapist consultation team (1 hour per week).
Intervention Type
Behavioral
Intervention Name(s)
Individual DBT with no DBT group sessions (DBT-I)
Other Intervention Name(s)
DBT, DBT-I
Intervention Description
Individual DBT (DBT-I) is 1 hour per week of individual therapy and 2.5 hours per week with the psychosocial activities group.
Intervention Type
Behavioral
Intervention Name(s)
Group Skills DBT with no DBT individual sessions (DBT-S)
Other Intervention Name(s)
DBT, DBT-S
Intervention Description
DBT group skills training is 2.5 hours per week and includes individual case management.
Primary Outcome Measure Information:
Title
Suicidal thoughts or attempts
Time Frame
Measured at Year 2
Secondary Outcome Measure Information:
Title
Coping skills
Time Frame
Measured at Year 2

10. Eligibility

Sex
Female
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
60 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Diagnosis of BPD At least one suicide attempt in the year prior to study entry AND at least one intentional self-injury within the 8 weeks prior to study entry Willing and able to comply with all study requirements Exclusion Criteria: IQ less than 70 Life-threatening anorexia Street homelessness with no contact information Admittance to a hospital with no expectation of discharge within 3 weeks prior to study entry OR sentenced to a jail or prison term that will last for more than 3 weeks Ordered by the court to receive psychological treatment Meet DSM-IV criteria for schizophrenia, bipolar disorder, or seizure disorder Medical conditions other than BPD that may interfere with the study
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Marsha M. Linehan, PhD
Organizational Affiliation
Department of Psychology, University of Washington
Official's Role
Principal Investigator
Facility Information:
Facility Name
University of Washington, Department of Psychology, Behavior Research and Therapy Clinics
City
Seattle
State/Province
Washington
ZIP/Postal Code
98195-1525
Country
United States

12. IPD Sharing Statement

Citations:
PubMed Identifier
1845222
Citation
Linehan MM, Armstrong HE, Suarez A, Allmon D, Heard HL. Cognitive-behavioral treatment of chronically parasuicidal borderline patients. Arch Gen Psychiatry. 1991 Dec;48(12):1060-4. doi: 10.1001/archpsyc.1991.01810360024003.
Results Reference
background
PubMed Identifier
7977884
Citation
Linehan MM, Tutek DA, Heard HL, Armstrong HE. Interpersonal outcome of cognitive behavioral treatment for chronically suicidal borderline patients. Am J Psychiatry. 1994 Dec;151(12):1771-6. doi: 10.1176/ajp.151.12.1771.
Results Reference
background
PubMed Identifier
12062776
Citation
Linehan MM, Dimeff LA, Reynolds SK, Comtois KA, Welch SS, Heagerty P, Kivlahan DR. Dialectical behavior therapy versus comprehensive validation therapy plus 12-step for the treatment of opioid dependent women meeting criteria for borderline personality disorder. Drug Alcohol Depend. 2002 Jun 1;67(1):13-26. doi: 10.1016/s0376-8716(02)00011-x.
Results Reference
background
PubMed Identifier
11525079
Citation
Swenson CR, Sanderson C, Dulit RA, Linehan MM. The application of dialectical behavior therapy for patients with borderline personality disorder on inpatient units. Psychiatr Q. 2001 Winter;72(4):307-24. doi: 10.1023/a:1010337231127.
Results Reference
background
PubMed Identifier
10598211
Citation
Linehan MM, Schmidt H 3rd, Dimeff LA, Craft JC, Kanter J, Comtois KA. Dialectical behavior therapy for patients with borderline personality disorder and drug-dependence. Am J Addict. 1999 Fall;8(4):279-92. doi: 10.1080/105504999305686.
Results Reference
background
PubMed Identifier
12562741
Citation
Verheul R, Van Den Bosch LM, Koeter MW, De Ridder MA, Stijnen T, Van Den Brink W. Dialectical behaviour therapy for women with borderline personality disorder: 12-month, randomised clinical trial in The Netherlands. Br J Psychiatry. 2003 Feb;182:135-40. doi: 10.1192/bjp.182.2.135.
Results Reference
background
PubMed Identifier
10957822
Citation
Bohus M, Haaf B, Stiglmayr C, Pohl U, Bohme R, Linehan M. Evaluation of inpatient dialectical-behavioral therapy for borderline personality disorder--a prospective study. Behav Res Ther. 2000 Sep;38(9):875-87. doi: 10.1016/s0005-7967(99)00103-5.
Results Reference
background
Citation
Koons, Cedar R; Robins, Clive J; Tweed, J. Lindsey; Lynch, Thomas R; Gonzalez, Alicia M; Morse, Jennifer Q; Bishop, G. Kay; Butterfield, Marian I; Bastian, Lori A. Efficacy of dialectical behavior therapy in women veterans with borderline personality disorder. Behavior Therapy. Vol 32(2) Spr 2001, 371-390
Results Reference
background
PubMed Identifier
33884617
Citation
Witt KG, Hetrick SE, Rajaram G, Hazell P, Taylor Salisbury TL, Townsend E, Hawton K. Psychosocial interventions for self-harm in adults. Cochrane Database Syst Rev. 2021 Apr 22;4(4):CD013668. doi: 10.1002/14651858.CD013668.pub2.
Results Reference
derived
PubMed Identifier
32368793
Citation
Storebo OJ, Stoffers-Winterling JM, Vollm BA, Kongerslev MT, Mattivi JT, Jorgensen MS, Faltinsen E, Todorovac A, Sales CP, Callesen HE, Lieb K, Simonsen E. Psychological therapies for people with borderline personality disorder. Cochrane Database Syst Rev. 2020 May 4;5(5):CD012955. doi: 10.1002/14651858.CD012955.pub2.
Results Reference
derived
PubMed Identifier
25806661
Citation
Linehan MM, Korslund KE, Harned MS, Gallop RJ, Lungu A, Neacsiu AD, McDavid J, Comtois KA, Murray-Gregory AM. Dialectical behavior therapy for high suicide risk in individuals with borderline personality disorder: a randomized clinical trial and component analysis. JAMA Psychiatry. 2015 May;72(5):475-82. doi: 10.1001/jamapsychiatry.2014.3039. Erratum In: JAMA Psychiatry. 2015 Sep;72(9):951.
Results Reference
derived
Links:
URL
http://depts.washington.edu/brtc/
Description
Click here for more information about the Behavioral Research and Therapy Clinics at the University of Washington

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Treatment of Suicidal Women With Borderline Personality Disorder

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