Haploidentical Stem Cell Transplantation for Patients With Hematologic Malignancies
Leukemia, Acute Lymphocytic (ALL), Leukemia, Myeloid, Acute(AML), Leukemia, Myeloid, Chronic(CML)
About this trial
This is an interventional treatment trial for Leukemia, Acute Lymphocytic (ALL) focused on measuring Haploidentical stem cell transplant, Allogeneic stem cell transplant, Mismatched family member stem cell donor transplant, Bone marrow transplantHigh risk hematologic malignancies
Eligibility Criteria
Inclusion Criteria: Lacking a HLA-identical sibling or unrelated donor matched at 6 HLA loci formally requested within an approximate 90 day period from search initiation and who has a mismatched family member donor available At least 2 and less than or equal to 21 years of age Must have one of the following diagnosis: Acute lymphoid leukemia (ALL) in second, third, or subsequent remission. ALL in first remission but high risk for relapse. Acute myeloid leukemia (AML) in relapse or remission. Secondary AML / MDS Chronic myeloid leukemia (CML) Juvenile myelomonocytic leukemia (JMML). Myelodysplastic syndrome (MDS). Paroxysmal nocturnal hemoglobinuria (PNH) Non-Hodgkin lymphoma in second or subsequent CR Patients with a shortening fraction ≥ 25% Patients with a creatinine clearance ≥ 40cc/min/1.73m^2 Patients with FVC ≥ 40% of predicted or pulse oximetry ≥ 92% on room air Patients with direct bilirubin ≤ 3 mg/dL or SGPT ≤ 500 U/L Patients with a Karnofsky or Lansky (age dependent) performance score of ≥ 70 Mismatched family member donor is available, HIV negative and ≥ 18 years of age Exclusion Criteria: Patients who have received a previous hematopoietic stem cell allograft Patients with a known allergy to rabbit or murine products Patients with isolated CNS, testicular or other isolated extramedullary site of relapse
Sites / Locations
- St. Jude Children's Research Hospital
Arms of the Study
Arm 1
Other
1