Study of Fentanyl-Propofol-EMLA of L.M.X4 Technique for Bone Marrow Aspiration
Bone Marrow Disease, Pain

About this trial
This is an interventional treatment trial for Bone Marrow Disease focused on measuring Pain Management, Bone Marrow Aspiration
Eligibility Criteria
Inclusion Criteria: Patients undergoing bone marrow aspiration (unilateral), with lumbar puncture and intrathecal chemotherapy. Age 2 to 17 years ASA I-III Patients with acute lymphoblastic leukemia or lymphoblastic lymphoma in remission or on the day of anticipated remission procedures occurring at the end of remission induction. Patients must have three anticipated bone marrow aspirates and lumbar punctures with intrathecal chemotherapy remaining in their treatment Exclusion Criteria: Newly diagnosed patients Patients with low platelet count (less than 50000) Patients undergoing bone marrow biopsy in addition to bone marrow aspiration Age less than 2 years or over 17 years ASA IV-V Patients taking opioid medication for pre-existent pain for more than 2 weeks at the time of the procedure Neurological impairment that would increase susceptibility to opioids (Down's syndrome) Clinical contraindications for general anesthesia (large mediastinal mass) or specific use of propofol, Fentanyl, EMLA, L•M•X 4™ or Lidocaine for injection
Sites / Locations
- St. Jude Children's Research Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Placebo Comparator
1
2
3
Fentanyl-1mcg/kg in 3 ml of Normal Saline
Fentanyl - 0.5 mcg/kg in 3 ml normal saline
normal saline