Treatment of Burkitt Lymphoma/Leukemia and B Large Cell NHL
Non-Hodgkin Lymphoma, Acute Lymphoblastic Leukemia, Mature B-Cell
About this trial
This is an interventional treatment trial for Non-Hodgkin Lymphoma focused on measuring Mature B-Cell Leukemia, Non-Hodgkin Lymphoma, Burkitt's lymphoma, Small noncleaved cell non Hodgkin lymphoma, Large cell lymphoma
Eligibility Criteria
Inclusion Criteria: Subject must be previously untreated, except for steroids. Subject must be less than or equal to 18 years of age. Subject must have a histologic diagnosis of small noncleaved cell (SNCC) NHL or large cell NHL (B-cell), or B-cell acute lymphocytic leukemia. Exclusion Criteria: Previously treated disease
Sites / Locations
- St. Jude Children's Research Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
A
B
C
Group A: Resected Stage I and resected abdominal Stage II Subjects will receive two courses (3 weeks apart) of COPAD.
Group B: Other Stage II, Stage III, Stage IV or B-ALL M blast <70%; no CNS involvement. Subjects in Group B will receive one week of treatment of COP.
Group C: B-ALL with >70% BM blasts; CNS involvement, Group B COP failures i.e., <20% reduction Treatment Pre-Induction Subjects will receive one week of treatment of COP.