B-Left HF: Biventricular Versus Left Univentricular Pacing With Implantable Cardiac Defibrillator (ICD) Back-Up in Heart Failure Patients
Heart Failure, Ventricular Dysfunction, Heart Diseases
About this trial
This is an interventional treatment trial for Heart Failure focused on measuring Ventricular Dyssynchrony
Eligibility Criteria
Inclusion Criteria: Have an approved indication for implantation of an ICD for treatment of a life-threatening ventricular tachyarrhythmia(s) Have advanced heart failure with a New York Heart Association (NYHA) classification of III or IV, despite receiving a minimum of 30 days of stable optimal pharmacological therapy Have a ventricular conduction delay manifested as a QRS width >= 130 ms Have a left ventricular end diastolic diameter (LVEDD) >= 55 mm Have a left ventricular ejection fraction (LVEF) <= 35% Exclusion Criteria: Have a CRT device already implanted Have a standard indication for bradycardia pacing Have a history of chronic atrial fibrillation [AF] (continuous AF lasting > 1 month) within 1 year prior to enrollment or have undergone cardioversion for AF in the past month) Have the ability to walk > 450 meters during the 6-minute walk test Have uncorrected primary valvular disease Have had a recent myocardial infarction, unstable angina or cardiac revascularization (percutaneous transluminal coronary angioplasty [PTCA] or coronary artery bypass graft [CABG]) within 1 month of enrollment Have had cerebrovascular accident (CVA) or transient ischemic attack (TIA) within 3 months of enrollment Have a life expectancy of less than one year Are unable to comply with the follow-up schedule and tests Are minors (age below 18 years) Are pregnant or are planning for pregnancy in the next 6 months
Sites / Locations
- Department of Cardiology - CHU Pontchaillou