Effects of N-Methyl-D-Aspartate (NMDA)-Receptor Antagonism on Hyperalgesia, Opioid Use, and Pain After Radical Prostatectomy
Hyperalgesia, Pain, Prostate Cancer
About this trial
This is an interventional educational/counseling/training trial for Hyperalgesia focused on measuring Hyperalgesia, Quantitative Sensory Testing, Pain, Opioid use, Elderly
Eligibility Criteria
Inclusion Criteria: Able to read and write English; Age 18-59 or >= 60 years; American Society of Anesthesiologists Class 1 to 3; Scheduled for elective radical prostatectomy; Body weight between 50-110 kg, body mass index (BMI) <= 30. Exclusion Criteria: Significant central nervous system (CNS), respiratory, cardiac, hepatic, renal or endocrine dysfunction and/or any significant sequelae; Contraindications, allergies to, and/or past adverse reactions to opioid analgesics, amantadine or nonsteroidal anti-inflammatory drugs (NSAIDS); Current Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM IV) Axis I disorder or cognitive dysfunction or history of this within the last year; History of epilepsy or other seizures; History of chronic pain of at least 6 months duration; History of long term opioid use for chronic pain of at least 6 months duration; History of long term use of amantadine or other antiparkinsonian drug; Ingestion of antitussive medication (dextromethorphan) within the 48 hours before surgery; History of alcohol or drug dependency/abuse of at least 6 months duration
Sites / Locations
- University Health NetworkRecruiting