Effect of the Menstrual Cycle on the Symptoms of Depression and Treatment Response
Major Depressive Disorder, Depression
About this trial
This is an interventional treatment trial for Major Depressive Disorder focused on measuring Major Depressive Disorder, Women's Mental Health, Hormones, Citalopram, Antidepressive agents, Mental Health
Eligibility Criteria
Inclusion Criteria: Women, ages 18-65 years old Fulfilling DSM-IV criteria for major depressive disorder, which is not secondary to another pre-existing psychiatric condition or to a medical condition Hamilton Depression Rating Scale (HAM-D-17) total score of at least 16 Able and willing to give meaningful written consent 28 women premenopausal (having monthly periods); 28 women perimenopausal (having irregular periods); and 28 women menopausal (without a period for at least one year). In good physical health. Exclusion Criteria: Subjects who are taking the birth control pill currently or within the last 3 months Subjects who plan to become pregnant or were pregnant within the last year Subjects who are taking hormone replacement therapy (or received it within the last three [3] months) Subjects who meet DSM-IV criteria for substance abuse (consume > 4 alcoholic beverages per day) Subjects who have tried 2 antidepressants for this episode Subjects who have additional diagnosed psychiatric conditions (i.e. anxiety, substance use and psychotic disorders) Subjects who have had both ovaries surgically removed.
Sites / Locations
- University Health Network