Mechanism of Fatty Acid-Induced Impairment of Glucose-Stimulated Insulin Secretion
Insulin Resistance Syndrome X, Pancreatic Beta Cell Function
About this trial
This is an interventional diagnostic trial for Insulin Resistance Syndrome X focused on measuring n-acetylcysteine,, free fatty acid,, glucose stimulated insulin secretion,, insulin resistance syndrome, antioxidant therapy, Insulin Resistance
Eligibility Criteria
Inclusion Criteria: The following criteria will be used for the selection of insulin resistant non-diabetic men aged 35-65 years: Written informed consent obtained Body mass index (BMI) > 27 kg/m2 Fasting triglycerides > 2 mmol/l and < 5 mmol/l Waist circumference > 90 cm Fasting blood glucose < 7 mmol/l In order to keep the number of study subjects to a minimum (n=15), in view of the cost of these labor-intensive metabolic studies, the investigators will be studying males only 35 to 65 years of age. This will allow them to study as homogeneous a group of subjects as possible. If significant protective effects of NAC on beta cell function are detected, they will study women using a similar protocol at a later stage. Hemoglobin above 130 g/L Exclusion Criteria: Patient has a history of hepatitis/hepatic disease that has been active within the previous two years Any significant active (over the past 12 months) disease of the gastrointestinal, pulmonary, neurological, renal (Cr > 1.5 mg/dL) genitourinary, hematological systems, or has severe uncontrolled treated or untreated hypertension (sitting diastolic BP > 100 or systolic > 180) or proliferative retinopathy Fasting blood glucose > 7 mmol/l or known diabetes Any history of a MI or clinically significant, active, cardiovascular history including a history of arrhythmias or conduction delays on ECG, unstable angina, or decompensated heart failure Any laboratory values: AST > 2x ULN; ALT > 2x ULN TSH > 6 mU/l Known or suspected allergy to the medication or a history of multiple and/or severe allergies to drugs or foods or a history of severe anaphylactic reactions Current addiction to alcohol or substances of abuse as determined by the investigator Mental incapacity, unwillingness or language barrier precluding adequate understanding or cooperation Any lipid lowering or hypoglycemic agents Previous history of asthma Will not donate blood three months prior to and three months post study procedures
Sites / Locations
- University Health Network