A Neuroimaging Investigation of Brain Activity in Major Depressive Disorder and Bipolar Disorder

Inclusion Criteria: (All three groups) age 18-55 years satisfactory physical health education level and a degree of understanding to communicate effectively with the investigator c capable of providing informed consent female subjects of childbearing potential, a medically accepted means of contraception. Additional inclusion criteria for the patient groups include DSM-IV-TR criteria for a diagnosis of BD or MDD currently meeting criteria for an MDE and a Hamilton Depression Rating Scale 17 Item (HDRS-17) score of > 17 blood indices within normal clinical ranges. Exclusion Criteria: (All three groups) DSM-IV-TR criteria for substance abuse or dependence (except nicotine or caffeine) within the past 6 months comorbid neurological or other major psychiatric disorders as defined in the DSM-IV-TR; history of neurological trauma resulting in loss of consciousness; uncorrected hypothyroidism or hyperthyroidism, including elevated thyroid stimulating hormone (TSH); other unstable medical condition; female subjects who are pregnant or nursing; Additional exclusion criteria for the BD and MDD group include: prior failure to respond to fluoxetine and olanzapine in combination at adequate dose and duration; evidence of serious risk of suicide based on clinician assessment and/or HRSD suicide item > 3; course of ECT (electroconvulsive therapy) in the preceding 6 months; Young Mania Rating Scale (YMRS) > 7; administration of fluoxetine within previous 4 weeks; treatment resistance as defined by the failure of two antidepressant trials from dissimilar classes Hyperglycemia or diabetes mellitus as defined by a fasting blood glucose value of > 125 mg/dl.