Effect of Two Versus Three Pneumococcal Conjugate Vaccinations (MNOES)
Streptococcus Pneumoniae Infection
About this trial
This is an interventional prevention trial for Streptococcus Pneumoniae Infection focused on measuring pneumococcal conjugate vaccination, nasopharyngeal carriage, herd immunity, antipneumococcal antibodies, respiratory tract infections, National infant vaccination program
Eligibility Criteria
Inclusion Criteria: Newborn infants eligible for participation in the national infant vaccination program in the Netherlands Exclusion Criteria: exclusion from the national vaccination program because of the presence of a medical condition requiring treatment that can interfere with the effect of vaccinations known or suspected allergy to components of the pneumococcal conjugate vaccine known or suspected immunodeficiency disease previous treatment with plasma or immunoglobulins previous vaccinations other than hepatitis B vaccinations coagulation disorders
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
No Intervention
2-dose
2+1-dose
Control
PCV7 at age 2 and 4 months
PCV7 at age 2, 4 and 11 months
Control group