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Malignant Obstruction ZILVER Against Routine Therapy (MOZART I)

Primary Purpose

Biliary Tract Neoplasms, Pancreatic Neoplasms, Jaundice, Obstructive

Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
6 mm Nitinol Zilver Stent
10 mm Nitinol Zilver Stent
10 mm Stainless Steel Wallstent
Sponsored by
Cook Group Incorporated
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Biliary Tract Neoplasms focused on measuring Stents, Stent-graft, Minimally invasive, Biliary Tract Cancer, Pancreatic Cancer, Jaundice, Biliary Tract Neoplasms, Pancreatic Neoplasms, Jaundice, Obstructive, Zilver

Eligibility Criteria

21 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria: Unresectable malignancy of the extrahepatic bile duct Exclusion Criteria: Age below 21 years Pregnancy Active alcohol or drug abuse Simultaneously participating in another investigational drug or device study. Allergy to stainless steel or nitinol Active cholangitis Brachytherapy Unable or unwilling to comply with follow up

Sites / Locations

  • Maine Medical Center

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

Active Comparator

Arm Label

6 mm Zilver

10 mm Zilver

10 mm Wallstent

Arm Description

6 mm Nitinol Zilver Stent

10 mm Nitinol Zilver Stent

10 mm Stainless Steel Wallstent

Outcomes

Primary Outcome Measures

Patency
Number of days of stent patency: The time to stent occlusion requiring re-intervention, death, loss to follow-up, or patients alive at study end without an occlusion (>= 6 months after placement).
Closure or Blockage of the Stent (Occlusion)
Biliary stents may become closed or blocked. This is also termed "Occlusion." Data for this outcome measure involve stent occlusions that required re-intervention.
Number of Days to Occlusion
Number of Deaths
Time to Death
Overall Survival

Secondary Outcome Measures

Full Information

First Posted
September 12, 2005
Last Updated
September 28, 2011
Sponsor
Cook Group Incorporated
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1. Study Identification

Unique Protocol Identification Number
NCT00196105
Brief Title
Malignant Obstruction ZILVER Against Routine Therapy (MOZART I)
Official Title
Multicenter Prospective Randomized Controlled Trial of the Nitinol ZILVER Expandable Endoprosthesis in the Palliation of Extrahepatic Malignant Biliary Obstruction
Study Type
Interventional

2. Study Status

Record Verification Date
September 2011
Overall Recruitment Status
Completed
Study Start Date
September 2003 (undefined)
Primary Completion Date
December 2006 (Actual)
Study Completion Date
December 2006 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Cook Group Incorporated

4. Oversight

5. Study Description

Brief Summary
This study compares the 6 mm nitinol Zilver biliary endoprostheses and the 10 mm nitinol Zilver biliary endoprostheses to the 10 mm Wallstent in appropriate patients in need of palliative treatment of malignant obstructive jaundice.
Detailed Description
This research is being done to determine if the new, FDA-cleared Zilver metal biliary stent is better than the conventional stents. The new Zilver stent may permit more accurate placement, may avoid some potential complications and last longer than the conventional stents. The study will also examine to find the best diameter of stent by comparing standard 10 mm stents to 6 mm Zilver stents.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Biliary Tract Neoplasms, Pancreatic Neoplasms, Jaundice, Obstructive
Keywords
Stents, Stent-graft, Minimally invasive, Biliary Tract Cancer, Pancreatic Cancer, Jaundice, Biliary Tract Neoplasms, Pancreatic Neoplasms, Jaundice, Obstructive, Zilver

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
241 (Actual)

8. Arms, Groups, and Interventions

Arm Title
6 mm Zilver
Arm Type
Experimental
Arm Description
6 mm Nitinol Zilver Stent
Arm Title
10 mm Zilver
Arm Type
Experimental
Arm Description
10 mm Nitinol Zilver Stent
Arm Title
10 mm Wallstent
Arm Type
Active Comparator
Arm Description
10 mm Stainless Steel Wallstent
Intervention Type
Device
Intervention Name(s)
6 mm Nitinol Zilver Stent
Intervention Type
Device
Intervention Name(s)
10 mm Nitinol Zilver Stent
Intervention Type
Device
Intervention Name(s)
10 mm Stainless Steel Wallstent
Primary Outcome Measure Information:
Title
Patency
Description
Number of days of stent patency: The time to stent occlusion requiring re-intervention, death, loss to follow-up, or patients alive at study end without an occlusion (>= 6 months after placement).
Time Frame
up to 32 months
Title
Closure or Blockage of the Stent (Occlusion)
Description
Biliary stents may become closed or blocked. This is also termed "Occlusion." Data for this outcome measure involve stent occlusions that required re-intervention.
Time Frame
up to 32 months
Title
Number of Days to Occlusion
Time Frame
up to 32 months
Title
Number of Deaths
Time Frame
up to 32 months
Title
Time to Death
Description
Overall Survival
Time Frame
up to 32 months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
21 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Unresectable malignancy of the extrahepatic bile duct Exclusion Criteria: Age below 21 years Pregnancy Active alcohol or drug abuse Simultaneously participating in another investigational drug or device study. Allergy to stainless steel or nitinol Active cholangitis Brachytherapy Unable or unwilling to comply with follow up
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Douglas Howell, M.D.
Organizational Affiliation
MaineHealth
Official's Role
Principal Investigator
Facility Information:
Facility Name
Maine Medical Center
City
Portland
State/Province
Maine
ZIP/Postal Code
04102
Country
United States

12. IPD Sharing Statement

Citations:
PubMed Identifier
19482279
Citation
Loew BJ, Howell DA, Sanders MK, Desilets DJ, Kortan PP, May GR, Shah RJ, Chen YK, Parsons WG, Hawes RH, Cotton PB, Slivka AA, Ahmad J, Lehman GA, Sherman S, Neuhaus H, Schumacher BM. Comparative performance of uncoated, self-expanding metal biliary stents of different designs in 2 diameters: final results of an international multicenter, randomized, controlled trial. Gastrointest Endosc. 2009 Sep;70(3):445-53. doi: 10.1016/j.gie.2008.11.018. Epub 2009 May 30.
Results Reference
result

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Malignant Obstruction ZILVER Against Routine Therapy (MOZART I)

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