Lactate Metabolism Study in HIV Infected Persons
HIV Infections, AIDS, Lactic Acidosis
About this trial
This is an interventional health services research trial for HIV Infections focused on measuring HIV, HIV/AIDS, Lactic Acidosis, Supplementation, Lactate Clearance, Mitochondrial Toxicity, HAART
Eligibility Criteria
Inclusion Criteria: Participants at least 18 years of age or older either: HIV negative, or HIV positive, not on antiretroviral therapy (for at least 6 months) or HIV positive, on D4T/ddC/ddI/AZT containing HAART or HIV positive, on D4T/ddC/ddI/AZT containing HAART, with hepatic steatosis/liver disease No evidence of acute illness on physical or laboratory examination Patients who have voluntarily consented to the study and signed the appropriate consent have not been supplementing with multi-vitamins, thiamine, riboflavin for at least 2 months prior to inclusion Exclusion Criteria: Active AIDS defining illness Treatment with growth hormone Known poor adherence with therapy End stage renal disease Pregnancy
Sites / Locations
- Queen's University
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
1
2
3
4
Individuals living with HIV who are naive to antiretroviral treatment, or who have been on a treatment interruption for at least six months
Individuals living with HIV who are on an antiretroviral regimen including one of D4T/ddI/ddC/AZT
Individuals living with HIV who are on an antiretroviral regimen including one of D4T/ddI/ddC/AZT and have liver disease.
HIV negative control group