Acid-Associated Heartburn Symptoms and Dose of Esomeprazole
Heartburn
About this trial
This is an interventional treatment trial for Heartburn
Eligibility Criteria
Inclusion Criteria: Males and non-lactating females, aged 18 to 75 years, inclusive, with the ability to understand English and provide written informed consent A history of heartburn for at least 6 months A history of prior positive relief of heartburn symptoms from antacids or acid suppressive therapy A positive esophageal acid perfusion test At least 3 days of 'moderate' severity heartburn over the previous 7 days No use of any acid suppression therapy (PPI, H2RA, etc.) within 14 days of randomization Exclusion Criteria: A history of gastric or esophageal surgery H. pylori positive A history of endoscopy -verified erosive esophagitis within the 16 weeks prior to randomization Currently taking higher than the standard approved proton pump inhibitor doses Historical evidence of a number of other GI, cardiovascular, pulmonary, liver, kidney, pancreatic, cerebral vascular diseases, organ transplant, or a condition requiring surgery.
Sites / Locations
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site
- Research Site