Treatment of Citalopram for Anxiety Disorders Following a Traumatic Brain Injury
Traumatic Brain Injury
About this trial
This is an interventional treatment trial for Traumatic Brain Injury focused on measuring Traumatic Brain Injury; Anxiety Disorders; SRI Treatment
Eligibility Criteria
Inclusion Criteria: Traumatic brain injury patients between 3 and 24 months post injury. Clear evidence/documentation of brain injury: i. documented/witnessed loss of consciousness, post traumatic amnesia ii. alteration in mental status (dazed/confused), and/or physical evidence of iii. trauma (MRI/CT hemorrhage/contusion) Traumatic brain injury with recovery to a Rancho los Amigos level 7 or 8 (alert and oriented). Meet criteria for DSM IV diagnosis Anxiety Disorder Due to a General Medical Condition. The symptoms of the anxiety disorder are not being controlled adequately with or without treatment at the time of referral. Military or Veteran beneficiary Men and non-pregnant/non-breastfeeding females Aged 18-65 Exclusion Criteria: Severe prior neurologic or psychiatric illness (based on DSM-IV criteria), such as stroke or psychosis. (Previous non-psychotic depression/anxiety is not an exclusion criterion) Current/prior unstable medical condition that could affect current brain function (ex. clear anoxic episode, cardiac arrest, current uncontrolled diabetes) Contraindication to the use of citalopram. Concomitant use of monoamine oxidase inhibitors (MAOIs), cimetidine, lithium, theophylline, digoxin, sumatriptan, warfarin, carbamazepine, triazolam, ketoconazole, CYP3A4 and 2C19 inhibitors, and metoprolol. Hypersensitivity to citalopram or any of the inactive ingredients in Celexa® Previous severe traumatic brain injury (defined as TBI with period of unconsciousness greater than 1 week. This exclusion refers only to TBIs prior to the current injury. Pregnancy (blood test required for females) Breastfeeding Current active suicidal ideation Inability to discontinue other psychotropic medications, such as tricyclic antidepressants or another SRI Current drug/alcohol abuse or dependence Previous unsuccessful trial of citalopram Participation in a concurrent drug or treatment trial
Sites / Locations
- Walter Reed Army Medical CenterRecruiting