Vinorelbine in Unresectable or Metastatic Esophageal and Gastric Adenocarcinoma
Esophageal Cancer, Gastric Cancer, Stomach Cancer
About this trial
This is an interventional treatment trial for Esophageal Cancer focused on measuring gastric adenocarcinoma, esophageal adenocarcinoma, vinorelbine
Eligibility Criteria
Inclusion Criteria: Locally unresectable or metastatic esophageal adenocarcinoma. Locally unresectable or metastatic gastric adenocarcinoma. Only patients with measurable tumors are eligible. No more than one prior chemotherapy regimen ECOG performance status of 0-1 Life expectancy of > 12 weeks Greater than or equal to 1,200 calorie/day intake ANC > 1,500/mm3 AST < 3 x ULN Total bilirubin < 2.0 ng/dl Platelets > 100,000/mm3 Serum creatinine < 2.0 mg/dl Exclusion Criteria: Prior therapy with vinca alkaloids Chemotherapy within the past three weeks Clinically apparent central nervous system metastases or carcinomatous meningitis Peripheral neuropathy > 1
Sites / Locations
- Massachusetts General Hospital
- Dana-Farber Cancer Institute