Back to resultsExercise-training Before Coronary Artery Bypass Graft (CABG)
Primary Purpose
Angina, Coronary Artery Disease
Status
Completed
Phase
Not Applicable
Locations
Norway
Study Type
Interventional
Intervention
Exercise training
Sponsored by
About this trial
This is an interventional basic science trial for Angina focused on measuring Aerobic capacity, Exercise training, CABG, Endothelial function
Eligibility Criteria
Inclusion Criteria: Scheduled for CABG both with and without heart failure Exclusion Criteria: Unstable angina Unable to walk on a treadmill (except those with heart failure who only will serve as a reference group) Participation in another study
Sites / Locations
- Norwegian University of Science and Technology
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
No Intervention
Arm Label
exercise training
physician's advice
Arm Description
patients follow their physician's advice in regard to physical activity.
Outcomes
Primary Outcome Measures
Cardiovascular function and quality of life
Secondary Outcome Measures
Structure and function of cardiomyocytes
Cardiomyocyte structure and function
Full Information
NCT ID
NCT00218985
First Posted
September 20, 2005
Last Updated
February 16, 2018
Sponsor
Norwegian University of Science and Technology
1. Study Identification
Unique Protocol Identification Number
NCT00218985
Brief Title
Exercise-training Before Coronary Artery Bypass Graft (CABG)
Official Title
Exercise-training Before Coronary Artery Bypass Graft (CABG)
Study Type
Interventional
2. Study Status
Record Verification Date
February 2018
Overall Recruitment Status
Completed
Study Start Date
January 2005 (Actual)
Primary Completion Date
December 2016 (Actual)
Study Completion Date
December 2016 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Norwegian University of Science and Technology
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small biopsy of the left ventricle obtained during surgery.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Angina, Coronary Artery Disease
Keywords
Aerobic capacity, Exercise training, CABG, Endothelial function
7. Study Design
Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Investigator
Allocation
Randomized
Enrollment
40 (Actual)
8. Arms, Groups, and Interventions
Arm Title
exercise training
Arm Type
Experimental
Arm Title
physician's advice
Arm Type
No Intervention
Arm Description
patients follow their physician's advice in regard to physical activity.
Intervention Type
Behavioral
Intervention Name(s)
Exercise training
Intervention Description
Intensity controlled exercise training before the scheduled bypass surgery
Primary Outcome Measure Information:
Title
Cardiovascular function and quality of life
Time Frame
Before and up to 1 year after intervention
Secondary Outcome Measure Information:
Title
Structure and function of cardiomyocytes
Time Frame
After the intervention period
Title
Cardiomyocyte structure and function
Time Frame
after the intervention period
10. Eligibility
Sex
All
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Scheduled for CABG both with and without heart failure
Exclusion Criteria:
Unstable angina
Unable to walk on a treadmill (except those with heart failure who only will serve as a reference group)
Participation in another study
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Ulrik Wisloff, Ph.D
Organizational Affiliation
Norwegian University of Science and Technology
Official's Role
Principal Investigator
Facility Information:
Facility Name
Norwegian University of Science and Technology
City
Trondheim
ZIP/Postal Code
7489
Country
Norway
12. IPD Sharing Statement
Citations:
PubMed Identifier
29447379
Citation
Smenes BT, Baekkerud FH, Slagsvold KH, Hassel E, Wohlwend M, Pinho M, Hoydal M, Wisloff U, Rognmo O, Wahba A. Acute exercise is not cardioprotective and may induce apoptotic signalling in heart surgery: a randomized controlled trial. Interact Cardiovasc Thorac Surg. 2018 Jul 1;27(1):95-101. doi: 10.1093/icvts/ivx439.
Results Reference
result
Learn more about this trial
Exercise-training Before Coronary Artery Bypass Graft (CABG)
We'll reach out to this number within 24 hrs