A Study Evaluating Efficacy, Toxicity, Harvest Yield and Quality of Life

Inclusion Criteria: Patients with active, symptomatic multiple myeloma without prior chemotherapy: Durie-Salmon Stage II-III A/B Stage I patients with at least 2 of the poor prognostic indicators may be eligible. Patients with plasma cell leukemia Non-secretory multiple myeloma patients are eligible Patients between the ages of 18 and 75 years old Female Patients of child bearing age (up to age 50) who are not pregnant and agree to use two adequate birth control methods during the study and at least six months after treatment unless patient has undergone hysterectomy or has been in menopause for 2 years. Patients with Southwest Oncology Group (SWOG) performance status of 3 or better Patients who have received prior lower dose Dexamethasone Therapy (ie. 4 mg QID) as adjunct to radiation therapy for cord compression may be eligible All patients must have a MUGA scan indicating a left ventricular ejection fraction (LVEF) of greater than or equal to 50% within 42 days prior to registration Must be able to understand English. Must be willing and eligible to sign up for the STEPS program Exclusion Criteria: Nursing mothers or women who are pregnant Patients with a history of hypersensitivity reaction to doxorubicin or agents in Doxil® Patients with previous malignancies at other sites except surgically treated nonmelanomatous skin cancers, prostate cancer or superficial cervical cancers, or other cancer from which the patient had been disease free for 5 or more years. History of mediastinal radiation for any reason History of receiving prior anthracyclines Patients with uncontrolled medical problems such as diabetes mellitus, cardiac, pulmonary, hepatic, and renal diseases unless renal insufficiency is felt to be secondary to multiple myeloma Myocardial infarction within 6 months of enrollment in the study. Major surgery within 4 weeks of enrollment. Patients previously treated or receiving other treatment for multiple myeloma other than lower doses dexamethasone as adjunct to radiotherapy Pre-existing peripheral neuropathy Patients with previously diagnosed malabsorption syndromes or anatomical abnormalities of the gastrointestinal tract that result in malabsorption syndromes. Patients with a history of cardiac disease, defined as New York Heart Association Class II or greater, or clinical evidence of congestive heart failure. Patients with psychiatric or central nervous systems disorders interfering with compliance of orally administered medication. Patients currently receiving anticoagulant therapy for venous thromboembolic episode or other hypercoagulable states. Patients who are unable to understand the English language.