Topiramate to Reduce Cocaine Dependence

Inclusion Criteria: Meets DSM-IV-TRTM diagnostic criteria for cocaine dependence Subjects must be non-treatment seeking, cocaine-dependent or cocaine-abusing individuals who report taking cocaine at least once a month In generally good health as confirmed by medical history, physical examination, electrocardiogram, laboratory screening tests, and vital signs Must be able to take oral medication, adhere to the medication regimens, and be willing to return to the clinic for regular study visits Must be able to read and understand all instructions, rating scales, and questionnaires in English Must be willing to stay overnight at the University Clinical Psychopharmacology Laboratory (UCPL) Must comply with the alcohol, tobacco, and drug-free environment regulations at the UCPL If female, must be postmenopausal for at least 1 year, surgically sterile, or willing to use contraception throughout the study Exclusion Criteria: History of mental illness, other than cocaine or nicotine dependence History of mental retardation or neuropsychological functioning greater than 1.5 standard deviation below expected rang. Clinically significant abnormalities found on the electrocardiogram History of hypertension (blood pressure greater than 140/90 mm Hg) or systolic hypotension (blood pressure less than 90/75 mm Hg) Resting pulse rate of greater than 90 beats per minute Cerebrovascular accident or transient ischemic attack Ischemic heart disease or heart attack Symptomatic coronary artery disease or peripheral vascular disease Cancer or history of cancer within the 5 years of study entry (other than basal cell carcinoma) Kidney disease and/or impaired kidney function, as defined by an estimated creatinine clearance of 60 mL per minute Gastrointestinal system disease, including active liver disease or current active hepatitis; subjects with AST and/or ALT levels greater than four times the upper limit of the normal range and/or an increased total serum bilirubin level greater than two times the upper limit of normal at screening Endocrinological disorders, including thyroid disorders Glaucoma Gross neurological disorders, including seizure disorders and progressive or degenerative neurological disorders (e.g., multiple sclerosis) History of nephrolithiasis Clinically significant laboratory screening test results on hematology, chemistry, or urine analysis; up to four times above the normal range of the following will be allowed unless there is evidence of hepatocellular disease or failure: liver enzymes (SGOT), serum glutamic pyruvic transaminase (SGPT), gamma-glutamyltransferase (GGT), blood urea nitrogen (BUN), lactate dehydrogenase (LDH) Any disease or condition that compromises the function of body systems that may result in altered absorption, excess accumulation, or impaired metabolism or excretion of topiramate Current use of psychoactive drugs, including sympathomimetics, caffeinated drinks in excess of 500 mg per day, and tobacco consumption of greater than 0.75 grams per day (approximately 25 cigarettes per day); non-pathological levels of alcohol consumption is permitted Suicide attempt or suicidal thoughts within 30 days of study entry Evidence of behavioral toxicity, including seizures, severe agitation, or psychosis Be taking a medication that could interact adversely with topiramate, unless the medication is discontinued. History of any severe or life-threatening medication interactions Currently taking any prescribed medications for heart or cerebrovascular disease Currently taking any medication with potential interactions with cocaine or topiramate, including glutamate antagonists (e.g., acamprosate), serotonin re-uptake inhibitors (e.g., fluoxetine), serotonin antagonists (e.g., ritanserin or buspirone), other antidepressants (e.g., tricyclic antidepressants or monoamine oxidase inhibitors), dopamine antagonists (e.g., haloperidol), calcium channel antagonists (e.g., isradipine), compounds with actions similar to disulfiram (Antabuse), or any carbonic anhydrase medication or medication containing triamterene Previously treated with topiramate for any reason and discontinued treatment due to an adverse event or a hypersensitivity reaction to topiramate Participation deemed unsafe because of precautions, warnings, or contraindications outlined in the topiramate investigator brochure and/or package insert, as determined by study investigator Expected to stay in a restricted environment or awaiting imprisonment Currently living in the same household as another study participant Received an investigational drug or device or participated in a clinical trial in the 30 days prior to study entry Employee of the investigator or study center Pregnant or breastfeeding