Neurocognitive Effects of Ziprasidone: Relationship to Working Memory and Dopamine Blockade
Schizophrenia
About this trial
This is an interventional treatment trial for Schizophrenia
Eligibility Criteria
Inclusion Criteria: Diagnosis of schizophrenia, schizoaffective disorder or schizophreniform disorder Ages 18 - 50 Ability to provide written informed consent Brief Psychiatric Rating Scale (BPRS) total score > 40 and Clinical Global Impressions (CGI) > 4 (moderately ill) and/or intolerant to current antipsychotic drug treatment Exclusion Criteria: History of prior treatment with ziprasidone History of medical condition that contraindicates ziprasidone treatment Treatment with depot antipsychotic medication in past 3 months Current diagnosis of alcohol or psychoactive substance dependence Impaired ability to provide written informed consent
Sites / Locations
- The Zucker Hillside Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
1
2
ziprasidone
risperidone or olanzapine