A Randomized Control Trial Comparing Quetiapine to Risperidone in Bipolar Disorder With Stimulant Dependence
Bipolar Disorder, Cocaine Dependence, Methamphetamine Dependence
About this trial
This is an interventional treatment trial for Bipolar Disorder focused on measuring Bipolar, cocaine, methamphetamine,quetiapine,risperidone
Eligibility Criteria
Inclusion criteria: English-speaking men and women (20-50 years old) of all ethnic origins Outpatients with a current DSM-IV diagnosis of bipolar I with or without psychotic features or bipolar II disorder Current cocaine or methamphetamine dependence Currently experiencing hypomanic, manic, or mixed state episodes with a Young Mania Rating Scale23 (YMRS11) score of > 9 Currently craving stimulants with a craving score of > 20 on the 10-item, self-reported Stimulant Craving Questionnaire24 (SCQ10) A high school diploma, GED, or Shipley IQ test score of >85. Exclusion criteria: Inpatients or anyone with a high risk for suicide (i.e., active suicidal ideation with a proposed plan, history of any suicide attempt within the last 6 months) DSM-IV diagnosis of substance-induced mood disorder Pregnant or breast-feeding History of special education, mental retardation, dementia HIV/AIDS, reactive hepatitis, hepatic cirrhosis or any active liver disease, personal or familial history of diabetes, personal history of heart disease (i.e., congenital heart abnormalities, congestive heart failure, chronic atrial fibrillation, rheumatic heart disease, heart attack) Central nervous system diseases (e.g., multiple sclerosis, severe head trauma, or seizures) Contraindications or allergic reactions to study medications Currently participating in any other research program Urine positive for glucose or ketones Currently receiving any antipsychotic medications or more than two psychotropic medications Currently receiving benzodiazepines, sedatives or stimulants Any other current substance dependence Cataracts or glaucoma EKG evidence of QT prolongation.
Sites / Locations
- University of Texas Southwestern Medical Center at Dallas
- Universty of North Texas Health Science Center
Arms of the Study
Arm 1
Active Comparator
1
Quetiapine versus Risperidone