Trial of Clopidogrel After Surgery for Coronary Artery Disease (CASCADE Trial) (CASCADE)
Atherosclerosis
About this trial
This is an interventional prevention trial for Atherosclerosis focused on measuring Saphenous vein, Intimal hyperplasia, Coronary artery bypass graft surgery, Antiplatelet therapy, Clopidogrel, Saphenous vein graft disease
Eligibility Criteria
Inclusion Criteria: Patients undergoing primary multi-vessel CABG with at least two saphenous vein grafts, with or without the use of cardiopulmonary bypass. Exclusion Criteria: Emergency surgery Valve surgery Redo CABG Left ventricle ejection fraction < 25% Serum creatinine > 130 µmol/L Preoperative use of clopidogrel (with the exception of the current admission) Preoperative use of warfarin; allergy to aspirin or clopidogrel. History of cerebrovascular accident History of severe liver disease Morbid obesity Current malignancy
Sites / Locations
- University of Ottawa Heart Institute
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
75mg Clopidogrel
Placebo
75mg clopidogrel. 162mg ASA is also given, but is a standard-of-care post operative to cardiac surgery.
Water pill. 162mg ASA is also given, but is a standard-of-care post operative to cardiac surgery.