Single Dose Azithromycin in the Treatment of Adult Cholera
Cholera
About this trial
This is an interventional treatment trial for Cholera focused on measuring Azithromycin, V. cholerae O1 / O139, adults, Bangladesh, Clinical trial
Eligibility Criteria
Inclusion Criteria: Age: 18 - 60 years Gender: Male (To facilitate accurate measurement of stool and urine, and also due to the difficulties in hospitalizing women for longer duration) Duration of illness: 24 hours or less Written informed consent for participation in the study Dehydration status: Signs of severe dehydration as determined by World Health Organization criteria. Positive stool dark-field microscopic examination for V. cholerae, and subsequent isolation of V. cholerae O1 or O139 from an admission culture of a stool or rectal swab sample. Exclusion Criteria: History of receiving even one dose of an antimicrobial agent effective in the treatment of cholera, and even a single fose of the drugs under evaluation. Concomitant infection requiring antimicrobial therapy other than the study drugs which may interfere with evaluation of either the efficacy or safety of the study drugs. A concomitant illness which may confound evaluation of outcome or is a contraindication for use of either of the study drugs (chronic heart, lung, of kidney disease, or instance), or conditions which may confound evaluation of adverse events of the study drugs.
Sites / Locations
- Dhaka Hospital, International Centre for Diarrhoeal Disease Research, Bangladesh