Carboplatin and Pemetrexed in Recurrent Platinum Sensitive Ovarian Cancer

Inclusion Criteria: Diagnosis of platinum-sensitive recurrence of epithelial ovarian cancer, primary peritoneal cancer, or fallopian tube cancer The following histologic subtypes are eligible: papillary serous, endometrioid, mucinous, clear cell, adenocarcinomas, transitional, and mixtures of the above. At least one measurable lesion according to RECIST criteria via CT or MRI scan Received a platinum-containing regimen at initial diagnosis ECOG performance status of 0,1 or 2 18 years of age or older Life expectancy of greater than 12 weeks WBC > 1,500/mm3 Neutrophils > 1,500/mm3 Platelets > 100,000/mm3 Total Bilirubin < 1.5 ULN Calculated creatinine clearance > 45 ml/min ALT/AST < 3 x ULN (no liver mets) ALT/AST < 5 x ULN (with liver mets) Complete recovery from completion of previous chemotherapy or biologic therapy Negative pregnancy test and agree to practice effective method of birth control Exclusion Criteria: Patients with sarcomatous, stromal, or germ cell elements Prior pelvic radiotherapy > 25% of bone marrow Uncontrolled medical problem that in the opinion of the investigator would preclude safe administration of the study drugs Past history of bone marrow transplantation or stem cell support Known history of CNS metastasis unless the patient has had treatment with surgery or radiation therapy, is neurologically stable, and does not require oral or intravenous corticosteroids or anticonvulsants Prior malignancy except adequately treated carcinoma in situ of the uterine cervix, incidental stage I endometrial cancer, basal cell or squamous cell skin cancer or breast cancer (invasive or ductal carcinoma in situ) of which the patient has been disease-free for at least five years Routine prophylactic use of G-CSF or GM-CSF or blood transfusions within 2 weeks Clinically significant cardiac disease as defined by: history of unstable angina within 6 months; history of symptomatic ventricular arrhythmias; history of congestive heart failure; history of myocardial infarction within 6 months Uncontrolled hypercalcemia or diabetes mellitus Any signs of intestinal obstruction with bowel function and/or nutrition Grade 2 or greater peripheral neuropathy Participation in an investigational study within three weeks History of anaphylactic shock to prior platinum chemotherapy History of psychiatric disability or other central nervous system disorder