A Comparison Of Outcomes In Patients In New York Heart Association (NYHA) Class II Heart Failure When Treated With Eplerenone Or Placebo In Addition To Standard Heart Failure Medicines (EMPHASIS-HF)
Heart Failure
About this trial
This is an interventional treatment trial for Heart Failure focused on measuring Open-label, single arm mortality/morbidity trial eplerenone chronic systolic heart failure
Eligibility Criteria
Inclusion Criteria: History (Hx) of chronic systolic heart failure of ischemic or non-ischemic etiology of at least 4 weeks duration; Currently, New York Heart Association (NYHA) functional Class II and on optimal dose, or maximally tolerated dose of standard heart failure medicines (advisable to include ACE-I/ARBs; beta-blockers) and diuretics if indicated for fluid overload. Should have participated in the double-blind phase of the EMPHASIS-HF trial Exclusion Criteria: Severe chronic systolic heart failure symptomatic at rest despite optimal medical therapy; estimated glomerular filtration rate (eGFR) <30 ml/min/1.73m2.
Sites / Locations
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Arms of the Study
Arm 1
Active Comparator
Eplerenone arm
Eplerenone administered on top of background standard heart failure therapy