Opiate Dependence: Combined Naltrexone/Behavior Therapy - 1
Heroin Dependence
About this trial
This is an interventional treatment trial for Heroin Dependence
Eligibility Criteria
Inclusion: Adult, aged 18-60. Meets DSM-IV criteria for current opiate dependence disorder of at least six months duration, supported by a positive urine for opiates and further by a positive naloxone challenge test if the diagnosis is unclear. Able to give informed consent. At least one significant other is willing to be interviewed for possible participation in the treatment. Exclusion: Pregnancy, lactation, or failure in a sexually active woman to use adequate contraceptive methods. Active medical illness which might make participation hazardous, such as untreated hypertension, unstable cardiovascular disease, acute hepatitis with SGOT or SGPT > 2-3 times normal, unstable diabetes, AIDS dementia. Active psychiatric disorder which might interfere with participation or make participation hazardous, including DSM-IV schizophrenia, bipolar disorder with mania or psychosis, and depressive disorder with suicide risk of 1 or more suicide attempts within the past year. History of allergic reaction to naloxone, naltrexone, buprenorphine, clonidine, or clonazepam. Currently prescribed or regularly taking opiates for chronic pain or medical illness. Current participation in another intensive treatment program or currently prescribed psychotropic medications in the last 30 days. Current participation in a Methadone Maintenance program and/or regular and/or Dependent use of street methadone. Opiate-dependent individuals who are seeking methadone maintenance treatment. History of accidental drug overdose in the last three years as defined as an episode of opioid-induced unconsciousness or incapacitation, whether or not medical treatment was sought or received.
Sites / Locations
- New York State Psychiatric Institute
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
CE plus oral naltrexone
BNT plus oral naltrexone
Compliance enhancement plus oral naltrexone
Behavioral naltrexone therapy plus oral naltrexone