BONSAI: Biomarkers of Nonsteroidal Anti-Inflammatories

Inclusion Criteria: Age 59 years or older at time of the first visit Family history of one or more first-degree relatives with Alzheimer-like dementia Fluency in written and spoken English Willingness to limit use of Vitamin E (<600 IU per day), Non-aspirin NSAIDs, Aspirin (<81mg per day), Histamine H2 receptor antagonists, and Gingko biloba extract for the duration of the study Ability and intention to participate in regular study visits Provision of informed consent Exclusion Criteria: History of peptic ulcer disease complicated by perforation, hemorrhage or obstruction History of uncomplicated peptic ulcer with symptoms in the 28 days prior to the first visit Clinically significant hypertension, anemia, liver disease, or kidney disease Hypersensitivity to aspirin or other NSAIDS Concurrent use of warfarin, ticlopidine, or any other type of anti-coagulant Concurrent use of systemic corticosteroids Use of ≥ 4 doses per week of either of the following in the 14 days prior to the first visit: Non-aspirin NSAIDs, Aspirin (>81mg per day), or Histamine H2 receptor antagonists Current plasma creatinine ≥1.5mg/dL Enrollment in any trial that is likely to interfere with BONSAI procedures or affect treatment outcomes Cognitive impairment or dementia