Prazosin for ETOH or Cocaine Craving
Alcoholism, Cocaine Dependence
About this trial
This is an interventional treatment trial for Alcoholism focused on measuring Alcoholism, Cocaine Dependence, Prazosin, Substance use disorders
Eligibility Criteria
Inclusion Criteria: Age 18-70 years Current DSM-IV diagnosis of alcohol dependence or cocaine dependence with no use in last 30 days Capacity to provide informed consent Actively enrolled in chemical dependency treatment at VA Puget Sound English fluency Exclusion Criteria: Evidence of significant abuse of opiates, PCP, sedatives or anxiolytics Suicidal ideation DSM IV diagnosis of bipolar mood disorder, schizophrenia or schizoaffective disorder Significant acute or chronic medical illness, including unstable angina, recent myocardial infarction, history of congestive heart failure, preexisting hypotension (systolic < 110), or orthostatic hypotension (systolic drop > 20mmHg after two minutes standing or any drop with dizziness), insulin-dependent diabetes mellitus; chronic renal or hepatic failure, pancreatitis, gout, M ni re's disease, benign positional vertigo, narcolepsy Concomitant use of alpha-1 antagonists History of prazosin-sensitivity Women who are pregnant, nursing infant(s), or of childbearing potential and not using a contraceptive method judged by the investigator to be effective Non-compliance with outpatient chemical dependency treatment
Sites / Locations
- VA Puget Sound Health Care System
Arms of the Study
Arm 1
Arm 2
Other
Active Comparator
Placebo
prazosin
Placebo no active medication
Prazosin flexible dose titration up to 12 mg per day.