Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome (JAPAN-ACS)
Coronary Disease, Hypercholesterolemia
About this trial
This is an interventional treatment trial for Coronary Disease focused on measuring Acute coronary syndrome, Hypercholesterolemia, Primary coronary intervention, Hydroxymethylglutaryl-CoA reductase inhibitors, coronary plaque, Angioplasty, Transluminal, Percutaneous Coronary, Ultrasonography, Interventional
Eligibility Criteria
Inclusion Criteria: Patients with written consent by their own volition after being provided sufficient explanation for their participation in this clinical trial Patients 20 years or older at the time of their consent Patients with hypercholesterolemia as defined by any of the following criteria: TC >= 220 mg/dL; LDL-C >= 140 mg/dL; Cholesterol-lowering treatment is necessary in accordance with the investigator's judgement when LDL-C >= 100 mg/dL or TC >= 180 mg/dL. Patients who have been diagnosed with acute coronary syndrome Patients with successful percutaneous coronary intervention (PCI) by intravascular ultrasound (IVUS) guidance Patients having coronary plaques (>= 500 µm in thickness or 20% or more in % plaque) at >= 5 mm from the previously treated area in the same branch of coronary artery Exclusion Criteria: Patients with bypass graft or in-stent restenosis at the site of PCI Patients who had received PCI on the lesion in the past where the evaluation of coronary plaque volume is planned Patients who had plaques in a non-culprit site and might receive PCI during the treatment period Patients receiving lipid-lowering drugs (statins, fibrates, probucol, nicotinic acid or cholesterol absorption inhibitors) Patients with familial hypercholesterolemia Patients with cardiogenic shock Patients receiving cyclosporine Patients with any allergy to pitavastatin or atorvastatin Patients with hepatobiliary disorders Pregnant women, women suspected of being pregnant, or lactating women Patients with renal disorders or undergoing dialysis Patients who are ineligible in the opinion of the investigator
Sites / Locations
- Juntendo University School of Medicine
- Yamaguchi University Graduate School of Medicine
- Kyoto University Graduate School of Medicine
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
1
2
Pitavastatin
Atorvastatin