Docetaxel and Radiation Therapy in Treating Patients With Stage II or Stage III Cancer of the Larynx or Hypopharynx
Head and Neck Cancer
About this trial
This is an interventional treatment trial for Head and Neck Cancer focused on measuring stage II squamous cell carcinoma of the hypopharynx, stage II squamous cell carcinoma of the larynx, stage III squamous cell carcinoma of the hypopharynx, stage III squamous cell carcinoma of the larynx
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed squamous cell carcinoma of the larynx or hypopharynx Stage II or III disease Solitary lymph node metastasis located in level II-III allowed Age 70 and over OR meets 1 of the following criteria: Creatinine clearance 30-60 mL/min History of platinum allergy Diagnosis of unstable angina Ineligible for systemic chemotherapy, including high-dose platinum-containing regimens PATIENT CHARACTERISTICS: Age See Disease Characteristics Performance status ECOG 0-2 Life expectancy Not specified Hematopoietic WBC > 3,000/mm^3 Neutrophil count > 1,500/mm^3 Hemoglobin > 10 g/dL Platelet count > 100,000/mm^3 Hepatic AST and ALT ≤ 2.0 times upper limit of normal Bilirubin < 2.0 mg/dL No severe liver disease Renal See Disease Characteristics Creatinine clearance ≥ 30 mL/min No severe renal disease Pulmonary No severe pulmonary disease Other No severe neurologic disease PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy No prior systemic chemotherapy Endocrine therapy Not specified Radiotherapy No prior radiotherapy Surgery No prior surgery
Sites / Locations
- Aichi Cancer Center
- Hirosaki University, School of Medicine
- Chiba University
- Yokohama City University
- Shinshu University Health Center
- Hamamatsu University School of Medicine
- National Hospital Organization - Medical Center of Kure
- Nara Medical University Cancer Center
- Graduate School of Medical Science at the University of Ryukyu