Combination Chemotherapy With or Without Surgery and Radiation Therapy in Treating Patients With Mesothelioma That Can Be Removed By Surgery
Malignant Mesothelioma
About this trial
This is an interventional treatment trial for Malignant Mesothelioma focused on measuring localized malignant mesothelioma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically and immuno-histochemically confirmed malignant mesothelioma Resectable disease (T1-3, N0-1, M0) with no distant metastases Eligible to undergo extra-pleural pneumonectomy based on British Thoracic Society guidelines PATIENT CHARACTERISTICS: Performance status WHO 0-1 Life expectancy Not specified Hematopoietic Not specified Hepatic Not specified Renal Normal renal function Cardiovascular Ejection fraction ≥ 40% Pulmonary Predicted post-operative FEV_1 ≥ 40% Predicted post-operative DLCO ≥ 40% No significant pulmonary hypertension Other No physical or personal condition that would preclude ability to undergo chemotherapy or post-operative radiotherapy No physical or personal condition that would preclude ability to comply with follow-up requirements PRIOR CONCURRENT THERAPY: Not specified
Sites / Locations
- Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust
- Birmingham Heartlands Hospital
- Bristol Royal Infirmary
- Queen's Hospital
- Addenbrooke's Hospital
- Papworth Hospital
- Ipswich Hospital
- Cookridge Hospital
- Leicester Royal Infirmary
- Glenfield Hospital
- St. Thomas' Hospital
- Royal Marsden - London
- Nottingham City Hospital NHS Trust
- Berkshire Cancer Centre at Royal Berkshire Hospital
- Cancer Research Centre at Weston Park Hospital
- Institute of Cancer Research - Sutton
- Royal Marsden - Surrey