search
Back to results

Fludarabine or Chlorambucil as First-Line Therapy in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia

Primary Purpose

Chronic Lymphocytic Leukemia

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Fludarabine
Chlorambucil
Sponsored by
German CLL Study Group
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Chronic Lymphocytic Leukemia focused on measuring stage 0 chronic lymphocytic leukemia, stage I chronic lymphocytic leukemia, stage II chronic lymphocytic leukemia, stage III chronic lymphocytic leukemia, stage IV chronic lymphocytic leukemia

Eligibility Criteria

65 Years - 79 Years (Older Adult)All SexesDoes not accept healthy volunteers

DISEASE CHARACTERISTICS: Confirmed diagnosis of chronic lymphocytic leukemia, meeting any of the following staging criteria: Binet stage A with B symptoms Binet stage B or C, meeting 1 of the following criteria: Rapid disease progression Enlarged lymph nodes and organs Severe B symptoms Previously untreated disease PATIENT CHARACTERISTICS: Performance status ECOG 0-2 Life expectancy More than 6 months Hematopoietic No thrombocytopenia No autoimmune hemolytic anemia Hepatic Not specified Renal Not specified Other No severe organ dysfunction No other prior or concurrent neoplasm PRIOR CONCURRENT THERAPY: Chemotherapy No prior chemotherapy No other concurrent chemotherapy

Sites / Locations

  • Hanuschkrankenhaus
  • Klinikum St. Marien
  • Gemeinschaftspraxis Fuer Innere Medizin, Haematologie Und Internistische Onkologie
  • Zentralklinikum Augsburg
  • Humaine - Clinic
  • Krankenhaus Hohe Warte Mediziniche Klinik
  • Onkologisches Versorgungszentrum Friedrichshain
  • Internistische Gemeinschaftspraxis - Berlin
  • Charite - Universitaetsmedizin Berlin - Campus Benjamin Franklin
  • Charite - Campus Virchow Klinikum
  • Saint Josef - Hospital Bochum
  • Praxis Dres. F.& G. Doering
  • Medizinische Universitaetsklinik I at the University of Cologne
  • Onkologische Schwerpunktpraxis
  • Onkologische Gemeinschaftspraxis - Dresden
  • Krankenhaus Benrath
  • Hans - Susemihl - Krankenhaus
  • Kreiskrankenhaus Erding
  • Internistische/Onkologische Praxis - Erfurt
  • Helios Klinikum Erfurt
  • Onkologische Schwerpunkt Praxis
  • Universitaetsklinikum Essen
  • Evangelisches Krankenhaus Essen Werden
  • Gemeinschaftspraxis - Freiburg
  • Klinikum Garmisch - Partenkirchen
  • Gemeinschaftspraxis Innere Medizin Hämatologie/Onkologie - Gera
  • Internistische Praxis - Gerlingen
  • Internistische Praxisgemeinschaft
  • Universitaetsklinikum Goettingen
  • Internistisch-Haematologische Gemeinschaftspraxis - Gustrow
  • Internistische Praxis - Halle
  • Internistische Gemeinschaftspraxis - Halle
  • Universitaetsklinikum Hamburg-Eppendorf
  • St. Marien-Hospital Hamm - Klinik Knappenstrasse
  • Schwerpunktpraxis Haematologie/Onkologie - Hannover
  • Eichsfeld Klinikum gGmbH
  • Medizinischen Klinik Dr. R. Schindlbeck
  • Oncological Specialist Practice
  • Universitaetsklinikum des Saarlandes
  • Clinic for Bone Marrow Transplantation and Hematology and Oncology
  • Westpfalz-Klinikum GmbH
  • Staedt Klinikum Karlsruhe GGMBH
  • Internistische Gemeinschaftspraxis - Kassel
  • Staedtische Krankenhaus Kiel
  • Krankenhaus Maria-Hilf Krefeld
  • Internistische Onkologische Praxis - Kronach
  • Internistische Praxis - Landshut
  • Klinikum Lippe - Lemgo
  • Internistische Praxis - Ludwigsburg
  • Kreiskrankenhaus Luedenscheid
  • III Medizinische Klinik Mannheim
  • Haematologisch-onkologische Gemeinschaftspraxis - Muenster
  • Regional Hospital Munchberg
  • Hamatologie/Onkologie Praxisgemeinschaft - Munchen
  • Klinikum Innenstadt
  • Krankenhaus Muenchen Schwabing
  • Hamatologische Schwerpunktpraxis
  • Munich Oncologic Practice at Elisenhof
  • Klinikum der Universitaet Muenchen - Grosshadern Campus
  • Staedtisches Krankenhaus Muenchen - Harlaching
  • Klinikum Rechts Der Isar - Technische Universitaet Muenchen
  • Onkologische Schwerpunktpraxis Dr. Schmidt
  • Praxis fuer Haematologie und Interne Onkologie
  • Praxisklinik fuer Innere Medizin - Nuernberg
  • Klinikum Nuernberg - Klinikum Nord
  • Internistische Gemeinschaftspraxis - Oberstaufen
  • Internistische Gemeinschaftspraxis - Offenbach
  • Internistische Gemeinschaftspraxis - Oldenburg
  • Klinikum Ernst Von Bergmann
  • Haematologische/Onkologische Schwerpunktpraxis - Rostock
  • Klinik und Poliklinik fuer Innere Medizin - Universitaet Rostock
  • Internistische Schwerpunktpraxis
  • Caritasklinik St. Theresia
  • Internistische Gemeinschaftspraxis - Saarbruecken
  • Schwerpunktpraxis Fuer Haematologie Und Onkologie
  • Kliniken Landkreis Sigmaringen GMBH
  • Internistische Gemeinschaftspraxis - Stuttgart
  • Marienhospital Stuttgart
  • Haematologische Praxis
  • Klinik fuer Onkologie - Katharinenhospital Stuttgart
  • Onkologische Gemeinschaftspraxis - Trier
  • Krankenanstalt Mutterhaus der Borromaerinnen
  • Southwest German Cancer Center at Eberhard-Karls-University
  • Universitaetsklinikum Ulm
  • St. Marien Hospital
  • Gemeinschaftspraxis
  • Kliniken St. Antonius
  • Hamatologisch - Onkologische Praxis Wurzburg

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

F

CLB

Arm Description

Fludarabine

Chlorambucil

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
December 6, 2005
Last Updated
May 21, 2019
Sponsor
German CLL Study Group
search

1. Study Identification

Unique Protocol Identification Number
NCT00262795
Brief Title
Fludarabine or Chlorambucil as First-Line Therapy in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia
Official Title
Fludarabine Versus Chlorambucil in First Line Therapy of Elderly Patients (More Than 65 Years) With Advanced Chronic Lymphocytic Leukemia
Study Type
Interventional

2. Study Status

Record Verification Date
May 2019
Overall Recruitment Status
Completed
Study Start Date
September 2003 (undefined)
Primary Completion Date
January 2005 (Actual)
Study Completion Date
October 2005 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
German CLL Study Group

4. Oversight

5. Study Description

Brief Summary
RATIONALE: Drugs used in chemotherapy, such as fludarabine and chlorambucil, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. It is not yet known whether fludarabine is more effective than chlorambucil in treating chronic lymphocytic leukemia. PURPOSE: This randomized phase III trial is studying fludarabine to see how well it works as first-line therapy compared to chlorambucil in treating older patients with previously untreated chronic lymphocytic leukemia.
Detailed Description
OBJECTIVES: Primary Compare the overall and progression-free survival of older patients with previously untreated chronic lymphocytic leukemia treated with fludarabine vs chlorambucil. Compare the duration of remission in patients treated with these regimens. Secondary Compare the incidence of toxicity, especially infections, in patients treated with these regimens. Compare the quality of life in patients treated with these regimens. OUTLINE: This is a randomized, multicenter study. Patients are randomized to 1 of 2 treatment arms. Arm I: Patients receive fludarabine IV on days 1-5. Treatment repeats every 28 days for up to 6 courses. Arm II: Patients receive oral chlorambucil on day 1. Treatment repeats every 15 days for up to 12 months. PROJECTED ACCRUAL: A total of 205 patients will be accrued for this study.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Chronic Lymphocytic Leukemia
Keywords
stage 0 chronic lymphocytic leukemia, stage I chronic lymphocytic leukemia, stage II chronic lymphocytic leukemia, stage III chronic lymphocytic leukemia, stage IV chronic lymphocytic leukemia

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
206 (Actual)

8. Arms, Groups, and Interventions

Arm Title
F
Arm Type
Experimental
Arm Description
Fludarabine
Arm Title
CLB
Arm Type
Active Comparator
Arm Description
Chlorambucil
Intervention Type
Drug
Intervention Name(s)
Fludarabine
Intervention Description
Fludarabine i.v. (25 mg/m2/d, d1-5) q28d; max 6 cycles
Intervention Type
Drug
Intervention Name(s)
Chlorambucil
Intervention Description
Chlorambucil p.o. (0,4 mg - max. 0,8 mg/kg/d, d1) q15d, max. 12 month

10. Eligibility

Sex
All
Minimum Age & Unit of Time
65 Years
Maximum Age & Unit of Time
79 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
DISEASE CHARACTERISTICS: Confirmed diagnosis of chronic lymphocytic leukemia, meeting any of the following staging criteria: Binet stage A with B symptoms Binet stage B or C, meeting 1 of the following criteria: Rapid disease progression Enlarged lymph nodes and organs Severe B symptoms Previously untreated disease PATIENT CHARACTERISTICS: Performance status ECOG 0-2 Life expectancy More than 6 months Hematopoietic No thrombocytopenia No autoimmune hemolytic anemia Hepatic Not specified Renal Not specified Other No severe organ dysfunction No other prior or concurrent neoplasm PRIOR CONCURRENT THERAPY: Chemotherapy No prior chemotherapy No other concurrent chemotherapy
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Michael Hallek, MD
Organizational Affiliation
Medizinische Universitaetsklinik I at the University of Cologne
Official's Role
Study Chair
Facility Information:
Facility Name
Hanuschkrankenhaus
City
Vienna
ZIP/Postal Code
A-1140
Country
Austria
Facility Name
Klinikum St. Marien
City
Amberg
ZIP/Postal Code
D-92224
Country
Germany
Facility Name
Gemeinschaftspraxis Fuer Innere Medizin, Haematologie Und Internistische Onkologie
City
Ansbach
ZIP/Postal Code
91522
Country
Germany
Facility Name
Zentralklinikum Augsburg
City
Augsburg
ZIP/Postal Code
DOH-86156
Country
Germany
Facility Name
Humaine - Clinic
City
Bad Saarow
ZIP/Postal Code
15526
Country
Germany
Facility Name
Krankenhaus Hohe Warte Mediziniche Klinik
City
Bayreuth
ZIP/Postal Code
95445
Country
Germany
Facility Name
Onkologisches Versorgungszentrum Friedrichshain
City
Berlin
ZIP/Postal Code
10249
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Berlin
City
Berlin
ZIP/Postal Code
14195
Country
Germany
Facility Name
Charite - Universitaetsmedizin Berlin - Campus Benjamin Franklin
City
Berlin
ZIP/Postal Code
D-12200
Country
Germany
Facility Name
Charite - Campus Virchow Klinikum
City
Berlin
ZIP/Postal Code
D-13353
Country
Germany
Facility Name
Saint Josef - Hospital Bochum
City
Bochum
ZIP/Postal Code
44791
Country
Germany
Facility Name
Praxis Dres. F.& G. Doering
City
Bremen
ZIP/Postal Code
28205
Country
Germany
Facility Name
Medizinische Universitaetsklinik I at the University of Cologne
City
Cologne
ZIP/Postal Code
D-50924
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis
City
Cottbus
ZIP/Postal Code
D-03046
Country
Germany
Facility Name
Onkologische Gemeinschaftspraxis - Dresden
City
Dresden
ZIP/Postal Code
01127
Country
Germany
Facility Name
Krankenhaus Benrath
City
Dusseldorf
ZIP/Postal Code
40593
Country
Germany
Facility Name
Hans - Susemihl - Krankenhaus
City
Emden
ZIP/Postal Code
D-26721
Country
Germany
Facility Name
Kreiskrankenhaus Erding
City
Erding
ZIP/Postal Code
85435
Country
Germany
Facility Name
Internistische/Onkologische Praxis - Erfurt
City
Erfurt
ZIP/Postal Code
99084
Country
Germany
Facility Name
Helios Klinikum Erfurt
City
Erfurt
ZIP/Postal Code
99089
Country
Germany
Facility Name
Onkologische Schwerpunkt Praxis
City
Erlangen
ZIP/Postal Code
D-91052
Country
Germany
Facility Name
Universitaetsklinikum Essen
City
Essen
ZIP/Postal Code
D-45122
Country
Germany
Facility Name
Evangelisches Krankenhaus Essen Werden
City
Essen
ZIP/Postal Code
D-45239
Country
Germany
Facility Name
Gemeinschaftspraxis - Freiburg
City
Freiburg
ZIP/Postal Code
79098
Country
Germany
Facility Name
Klinikum Garmisch - Partenkirchen
City
Garmisch-Partenkirchen
ZIP/Postal Code
N 82467
Country
Germany
Facility Name
Gemeinschaftspraxis Innere Medizin Hämatologie/Onkologie - Gera
City
Gera
ZIP/Postal Code
07548
Country
Germany
Facility Name
Internistische Praxis - Gerlingen
City
Gerlingen
ZIP/Postal Code
70839
Country
Germany
Facility Name
Internistische Praxisgemeinschaft
City
Germering
ZIP/Postal Code
82110
Country
Germany
Facility Name
Universitaetsklinikum Goettingen
City
Goettingen
ZIP/Postal Code
D-37075
Country
Germany
Facility Name
Internistisch-Haematologische Gemeinschaftspraxis - Gustrow
City
Gustrow
ZIP/Postal Code
18273
Country
Germany
Facility Name
Internistische Praxis - Halle
City
Halle
ZIP/Postal Code
06108
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Halle
City
Halle
ZIP/Postal Code
06110
Country
Germany
Facility Name
Universitaetsklinikum Hamburg-Eppendorf
City
Hamburg
ZIP/Postal Code
D-20246
Country
Germany
Facility Name
St. Marien-Hospital Hamm - Klinik Knappenstrasse
City
Hamm
ZIP/Postal Code
D-59071
Country
Germany
Facility Name
Schwerpunktpraxis Haematologie/Onkologie - Hannover
City
Hannover
ZIP/Postal Code
30169
Country
Germany
Facility Name
Eichsfeld Klinikum gGmbH
City
Heiligenstadt
ZIP/Postal Code
37339
Country
Germany
Facility Name
Medizinischen Klinik Dr. R. Schindlbeck
City
Herrsching
ZIP/Postal Code
82211
Country
Germany
Facility Name
Oncological Specialist Practice
City
Hildesheim
ZIP/Postal Code
31134
Country
Germany
Facility Name
Universitaetsklinikum des Saarlandes
City
Homburg
ZIP/Postal Code
D-66421
Country
Germany
Facility Name
Clinic for Bone Marrow Transplantation and Hematology and Oncology
City
Idar-Oberstein
ZIP/Postal Code
D-55743
Country
Germany
Facility Name
Westpfalz-Klinikum GmbH
City
Kaiserslautern
ZIP/Postal Code
D-67653
Country
Germany
Facility Name
Staedt Klinikum Karlsruhe GGMBH
City
Karlsruhe
ZIP/Postal Code
76133
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Kassel
City
Kassel
ZIP/Postal Code
34117
Country
Germany
Facility Name
Staedtische Krankenhaus Kiel
City
Kiel
ZIP/Postal Code
23116
Country
Germany
Facility Name
Krankenhaus Maria-Hilf Krefeld
City
Krefeld
ZIP/Postal Code
47805
Country
Germany
Facility Name
Internistische Onkologische Praxis - Kronach
City
Kronach
ZIP/Postal Code
96317
Country
Germany
Facility Name
Internistische Praxis - Landshut
City
Landshut
ZIP/Postal Code
84028
Country
Germany
Facility Name
Klinikum Lippe - Lemgo
City
Lemgo
ZIP/Postal Code
D-32657
Country
Germany
Facility Name
Internistische Praxis - Ludwigsburg
City
Ludwigsburg
ZIP/Postal Code
71638
Country
Germany
Facility Name
Kreiskrankenhaus Luedenscheid
City
Luedenscheid
ZIP/Postal Code
58515
Country
Germany
Facility Name
III Medizinische Klinik Mannheim
City
Mannheim
ZIP/Postal Code
D-68305
Country
Germany
Facility Name
Haematologisch-onkologische Gemeinschaftspraxis - Muenster
City
Muenster
ZIP/Postal Code
48149
Country
Germany
Facility Name
Regional Hospital Munchberg
City
Munchber
ZIP/Postal Code
D-95213
Country
Germany
Facility Name
Hamatologie/Onkologie Praxisgemeinschaft - Munchen
City
Munchen
ZIP/Postal Code
81245
Country
Germany
Facility Name
Klinikum Innenstadt
City
Munich
ZIP/Postal Code
80331
Country
Germany
Facility Name
Krankenhaus Muenchen Schwabing
City
Munich
ZIP/Postal Code
80804
Country
Germany
Facility Name
Hamatologische Schwerpunktpraxis
City
Munich
ZIP/Postal Code
81679
Country
Germany
Facility Name
Munich Oncologic Practice at Elisenhof
City
Munich
ZIP/Postal Code
D-80335
Country
Germany
Facility Name
Klinikum der Universitaet Muenchen - Grosshadern Campus
City
Munich
ZIP/Postal Code
D-81377
Country
Germany
Facility Name
Staedtisches Krankenhaus Muenchen - Harlaching
City
Munich
ZIP/Postal Code
D-81545
Country
Germany
Facility Name
Klinikum Rechts Der Isar - Technische Universitaet Muenchen
City
Munich
ZIP/Postal Code
D-81675
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis Dr. Schmidt
City
Neunkirchen
ZIP/Postal Code
D-66538
Country
Germany
Facility Name
Praxis fuer Haematologie und Interne Onkologie
City
Norderstedt
ZIP/Postal Code
22844
Country
Germany
Facility Name
Praxisklinik fuer Innere Medizin - Nuernberg
City
Nuernberg
ZIP/Postal Code
90449
Country
Germany
Facility Name
Klinikum Nuernberg - Klinikum Nord
City
Nuernberg
ZIP/Postal Code
D-90419
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Oberstaufen
City
Oberstaufen
ZIP/Postal Code
87534
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Offenbach
City
Offenbach
ZIP/Postal Code
63065
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Oldenburg
City
Oldenburg
ZIP/Postal Code
26121
Country
Germany
Facility Name
Klinikum Ernst Von Bergmann
City
Postdam
ZIP/Postal Code
D-14467
Country
Germany
Facility Name
Haematologische/Onkologische Schwerpunktpraxis - Rostock
City
Rostock
ZIP/Postal Code
18057
Country
Germany
Facility Name
Klinik und Poliklinik fuer Innere Medizin - Universitaet Rostock
City
Rostock
ZIP/Postal Code
D-18057
Country
Germany
Facility Name
Internistische Schwerpunktpraxis
City
Russelsheim
ZIP/Postal Code
65428
Country
Germany
Facility Name
Caritasklinik St. Theresia
City
Saarbrucken
ZIP/Postal Code
D-66113
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Saarbruecken
City
Saarbruecken
ZIP/Postal Code
66121
Country
Germany
Facility Name
Schwerpunktpraxis Fuer Haematologie Und Onkologie
City
Saarbruecke
ZIP/Postal Code
N-66113
Country
Germany
Facility Name
Kliniken Landkreis Sigmaringen GMBH
City
Sigmaringen
ZIP/Postal Code
D-72488
Country
Germany
Facility Name
Internistische Gemeinschaftspraxis - Stuttgart
City
Stuttgart
ZIP/Postal Code
70176
Country
Germany
Facility Name
Marienhospital Stuttgart
City
Stuttgart
ZIP/Postal Code
70199
Country
Germany
Facility Name
Haematologische Praxis
City
Stuttgart
ZIP/Postal Code
D-70173
Country
Germany
Facility Name
Klinik fuer Onkologie - Katharinenhospital Stuttgart
City
Stuttgart
ZIP/Postal Code
D-70174
Country
Germany
Facility Name
Onkologische Gemeinschaftspraxis - Trier
City
Trier
ZIP/Postal Code
54290
Country
Germany
Facility Name
Krankenanstalt Mutterhaus der Borromaerinnen
City
Trier
ZIP/Postal Code
D-54290
Country
Germany
Facility Name
Southwest German Cancer Center at Eberhard-Karls-University
City
Tuebingen
ZIP/Postal Code
D-72076
Country
Germany
Facility Name
Universitaetsklinikum Ulm
City
Ulm
ZIP/Postal Code
D-89081
Country
Germany
Facility Name
St. Marien Hospital
City
Vechta
ZIP/Postal Code
D-49377
Country
Germany
Facility Name
Gemeinschaftspraxis
City
Worms
ZIP/Postal Code
DOH-67547
Country
Germany
Facility Name
Kliniken St. Antonius
City
Wuppertal 2
ZIP/Postal Code
D-42283
Country
Germany
Facility Name
Hamatologisch - Onkologische Praxis Wurzburg
City
Wurzburg
ZIP/Postal Code
97070
Country
Germany

12. IPD Sharing Statement

Citations:
PubMed Identifier
21139079
Citation
Eichhorst BF, Fischer K, Fink AM, Elter T, Wendtner CM, Goede V, Bergmann M, Stilgenbauer S, Hopfinger G, Ritgen M, Bahlo J, Busch R, Hallek M; German CLL Study Group (GCLLSG). Limited clinical relevance of imaging techniques in the follow-up of patients with advanced chronic lymphocytic leukemia: results of a meta-analysis. Blood. 2011 Feb 10;117(6):1817-21. doi: 10.1182/blood-2010-04-282228. Epub 2010 Dec 7.
Results Reference
background
PubMed Identifier
24412156
Citation
Cramer P, Bahlo J, Eichhorst B, Fischer K, Hallek M. Extramedullary manifestations of chronic lymphocytic leukaemia are not unusual. Leuk Res. 2014 Mar;38(3):284-5. doi: 10.1016/j.leukres.2013.11.015. Epub 2013 Dec 1. No abstract available.
Results Reference
background
PubMed Identifier
24584349
Citation
Goede V, Cramer P, Busch R, Bergmann M, Stauch M, Hopfinger G, Stilgenbauer S, Dohner H, Westermann A, Wendtner CM, Eichhorst B, Hallek M; German CLL Study Group. Interactions between comorbidity and treatment of chronic lymphocytic leukemia: results of German Chronic Lymphocytic Leukemia Study Group trials. Haematologica. 2014 Jun;99(6):1095-100. doi: 10.3324/haematol.2013.096792. Epub 2014 Feb 28.
Results Reference
background
PubMed Identifier
31092457
Citation
Sachanas S, Pangalis GA, Fink AM, Bahlo J, Fischer K, Levidou G, Kyrtsonis MC, Bartzi V, Vassilakopoulos TP, Kalpadakis C, Koulieris E, Moschogiannis M, Yiakoumis X, Tsirkinidis P, Angelopoulou MK, Eichhorst B, Hallek M. Small Lymphocytic Lymphoma: Analysis of Two Cohorts Including Patients in Clinical Trials of the German Chronic Lymphocytic Leukemia Study Group (GCLLSG) or in "Real-Life" Outside of Clinical Trials. Anticancer Res. 2019 May;39(5):2591-2598. doi: 10.21873/anticanres.13382.
Results Reference
background
PubMed Identifier
19605849
Citation
Eichhorst BF, Busch R, Stilgenbauer S, Stauch M, Bergmann MA, Ritgen M, Kranzhofer N, Rohrberg R, Soling U, Burkhard O, Westermann A, Goede V, Schweighofer CD, Fischer K, Fink AM, Wendtner CM, Brittinger G, Dohner H, Emmerich B, Hallek M; German CLL Study Group (GCLLSG). First-line therapy with fludarabine compared with chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia. Blood. 2009 Oct 15;114(16):3382-91. doi: 10.1182/blood-2009-02-206185. Epub 2009 Jul 15.
Results Reference
result
Links:
URL
http://www.dcllsg.de/en/trial/cll5/index.php
Description
Click here for more information about this study: CLL5 (German CLL Study Group)

Learn more about this trial

Fludarabine or Chlorambucil as First-Line Therapy in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia

We'll reach out to this number within 24 hrs