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Patupilone Versus Doxorubicin in Patients With Ovarian, Primary Fallopian, or Peritoneal Cancer

Primary Purpose

Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Neoplasms

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
EPO906 (Patupilone)
doxorubicin
Sponsored by
Novartis Pharmaceuticals
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Ovarian Cancer focused on measuring Epithelial ovarian cancer, fallopian tube cancer, peritoneal cancer, primary cancer, recurrent cancer, doxorubicin, taxane chemotherapy, platinum chemotherapy, Patupilone, taxane platinum resistant

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)FemaleDoes not accept healthy volunteers

Inclusion Criteria: 18 years of age or older Confirmed diagnosis of ovarian, fallopian or peritoneal cancer No more than three chemotherapy regimens Most recent regimen must have been platinum based Exclusion Criteria: Have an unresolved bowel obstruction Have had previous chemotherapy within 3 weeks Recovering from any surgery for any cause Other protocol-defined inclusion/exclusion criteria will apply.

Sites / Locations

  • Alaska Cancer Research & Education Center
  • Northern Arizona Hematology & Oncology Associates
  • Mayo Center for Women's Health
  • Northern Arizona Hematology & Oncology Associates
  • Genesis Cancer Center
  • University of Arkansas for Medical Sciences
  • Yanagihara, Ronald H.
  • California Cancer Care, Inc.
  • University of California - San Diego/ Moores Cancer Center
  • LAC & USC Women's & Children's Hospital
  • Gynecologic Oncology associates
  • UC Davis Cancer Center
  • California Pacific Medical Center Research Institute
  • Anschutz Cancer Pavilion
  • Anschutz Cancer Pavilion - Clinical Investigations Core
  • University Of Colorado Health Sciences Center
  • Yale University School of Medicine
  • Christiana Gynecologic Oncology, LLC
  • Washington Hospital Center/Medstar Research Institute
  • Florida Gynecologic Oncology
  • Miami Cancer Center at Mercy Hospital
  • Miami Cancer Center at University Hospital
  • University of Miami
  • Mt. Sinai Medical Center
  • Advanced Medical Specialties
  • Ocala Oncology Center
  • MD Anderson Cancer Center of Orlando
  • Oncology & Hematology Associates of West Broward
  • Xelero Medical Research/Giselle Ghurani
  • Medical College of Georgia
  • Memorial Health University Medical Center
  • Kapiolani Medical Center for Women and Children/Univ. of HI
  • Northwest Memorial Hospital
  • Rush University Medical Center
  • Cancer Institute of Central Illinois/Decatur Memorial Hospital
  • Indiana University Obstetrics
  • Indiana University Cancer Center/Indiana UNiversity Melvin & Bren Simon Cancer Center
  • Gynecologic Oncology of Indiana/St. Francis Cancer Research Foundation
  • Northern Indiana Cancer Research Consortium
  • Louisville Oncology
  • Franklin Square Hospital Center
  • Boston University Medical Center Hospital
  • Providence Cancer Center
  • Minnesota Oncology/Hematology, PA
  • St. Luke's Hospital
  • Minnesota Oncology/Hematology, PA
  • Minnesota Oncology/Hematology Associates of Central Illinois
  • University of Minnesota
  • Metro-MN CCOP
  • Minnesota Oncology Hematology
  • The West Clinic
  • The West Clinic
  • St. Luke's Hospital of Kansas City/St. Luke's Cancer Institute
  • Washington University School of Medicine
  • Southeast Nebraska Oncology/Southeast Nebraska Cancer Center
  • Comprehensive Cancer Centers of Nevada
  • Women's Cancer Center of Nevada
  • Dartmouth-Hitchcock Medical Center
  • Hematology and Oncology Associates of Northern New Jersey
  • University of Medicine and Dentistry of New Jersey/The Cancer Institute of Neew Jersey
  • New York Oncology Hematology, P.C.
  • Schwartz Gynecologic Oncology, PLLC
  • Bellview Hospital
  • New York University School of Medicine/NYU Cancer Institute
  • NYU Cancer Institute
  • St. Vincent Catholic Medical Center of New York
  • Brody School of Medicine
  • New Hanover Regional Medical Center/Zimmer Cancer Center
  • Ohio State University Medical Center
  • Camelot Women's Cancer
  • The Arthur G. James Cancer Hospital
  • Cancer Care Associates
  • Oncology Associates of Oregon, PC/Willaimette Valley Cancer Center
  • Northwest Cancer Specialists, P.C.
  • Willamette Valley Cancer Center
  • Medical Oncology Associates of Wyoming Valley, PC
  • Magee - Women's Hospital
  • GYN Oncology Research/Gynecologic Oncology Research & Development, LLC
  • Chattanooga GYN Oncology
  • Hall and Martin MDs, PC
  • The West Clinic
  • West Clinic
  • Texas Oncology, P.A.
  • Texas Oncology
  • Texas Oncology, P.A.
  • Texas Oncology, P.A.
  • Sammons Cancer Center
  • Texas Oncology, P.A.
  • Texas Oncology, P.A.
  • Oncology Consultants P.A.
  • Cancer Care Center of South Texas
  • Waco Cancer Care & Research Center
  • Utah Cancer Specialists
  • Fletcher Allen Health Care
  • Cancer Outreach Associates
  • Northern Virginia Pelvic Surgery Associates
  • Virginia Oncology Associates
  • Virginia Oncology Associates
  • Virginia Commonwealth University/VCU Massey Cancer Center
  • Gersh, Robert
  • Northwest Cancer Specialists, P.C.
  • Northwest Cancer Specialists
  • Yakima Valley Memorial Hospital
  • Aurora Medical Gyn Group
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • BC Cancer Agency
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site
  • Novartis Investigative Site

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Patupilone

doxorubicin

Arm Description

Outcomes

Primary Outcome Measures

To show superiority of patupilone in overall survival compared to doxorubicin in taxane/platinum resistant patients with ovarian cancer

Secondary Outcome Measures

To determine the duration of overall response in patients with complete response (CR) or partial response (PR) or stable disease (SD)
To determine the progression-free survival (PFS) of patients treated with patupilone
To determine the time to disease progression (TTP) of patients treated with patupilone
To determine overall best tumor response (CR, PR, SD, PD and Unknown)
To investigate the safety and tolerability of patupilone
To evaluate the pharmacokinetics (PK) of patupilone from all patients
To explore relationships between Cmin (pre-dose patupilone blood concentration) and efficacy/adverse events

Full Information

First Posted
December 6, 2005
Last Updated
December 11, 2020
Sponsor
Novartis Pharmaceuticals
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1. Study Identification

Unique Protocol Identification Number
NCT00262990
Brief Title
Patupilone Versus Doxorubicin in Patients With Ovarian, Primary Fallopian, or Peritoneal Cancer
Official Title
A Randomized, Parallel Group, Open-label, Active Controlled, Multicenter Phase III Trial of Patupilone (EPO906) Versus Pegylated Liposomal Doxorubicin in Taxane/Platinum Refractory/Resistant Patients With Recurrent Epithelial Ovarian, Primary Fallopian or Primary Peritoneal Cancer
Study Type
Interventional

2. Study Status

Record Verification Date
May 2012
Overall Recruitment Status
Completed
Study Start Date
November 2005 (undefined)
Primary Completion Date
February 2010 (Actual)
Study Completion Date
undefined (undefined)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Novartis Pharmaceuticals

4. Oversight

5. Study Description

Brief Summary
The objective of this study is to assess the safety and efficacy of patupilone compared to pegylated liposomal doxorubicin. Additionally, this study will assess the ability of patupilone to extend the survival time and potential beneficial effects in women who have nonresponsive or recurrent ovarian, primary fallopian, or primary peritoneal cancer.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Neoplasms
Keywords
Epithelial ovarian cancer, fallopian tube cancer, peritoneal cancer, primary cancer, recurrent cancer, doxorubicin, taxane chemotherapy, platinum chemotherapy, Patupilone, taxane platinum resistant

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
829 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Patupilone
Arm Type
Experimental
Arm Title
doxorubicin
Arm Type
Active Comparator
Intervention Type
Drug
Intervention Name(s)
EPO906 (Patupilone)
Other Intervention Name(s)
Patupilone
Intervention Type
Drug
Intervention Name(s)
doxorubicin
Primary Outcome Measure Information:
Title
To show superiority of patupilone in overall survival compared to doxorubicin in taxane/platinum resistant patients with ovarian cancer
Time Frame
every 8 weeks
Secondary Outcome Measure Information:
Title
To determine the duration of overall response in patients with complete response (CR) or partial response (PR) or stable disease (SD)
Time Frame
End of study
Title
To determine the progression-free survival (PFS) of patients treated with patupilone
Time Frame
end of study
Title
To determine the time to disease progression (TTP) of patients treated with patupilone
Time Frame
end of study
Title
To determine overall best tumor response (CR, PR, SD, PD and Unknown)
Time Frame
end of study
Title
To investigate the safety and tolerability of patupilone
Time Frame
end of study
Title
To evaluate the pharmacokinetics (PK) of patupilone from all patients
Time Frame
end of study
Title
To explore relationships between Cmin (pre-dose patupilone blood concentration) and efficacy/adverse events
Time Frame
end of study

10. Eligibility

Sex
Female
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: 18 years of age or older Confirmed diagnosis of ovarian, fallopian or peritoneal cancer No more than three chemotherapy regimens Most recent regimen must have been platinum based Exclusion Criteria: Have an unresolved bowel obstruction Have had previous chemotherapy within 3 weeks Recovering from any surgery for any cause Other protocol-defined inclusion/exclusion criteria will apply.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Novartis Pharmaceuticals
Organizational Affiliation
Novartis Pharmaceuticals
Official's Role
Study Director
Facility Information:
Facility Name
Alaska Cancer Research & Education Center
City
Anchorage
State/Province
Alaska
ZIP/Postal Code
99508
Country
United States
Facility Name
Northern Arizona Hematology & Oncology Associates
City
Flagstaff
State/Province
Arizona
ZIP/Postal Code
86001
Country
United States
Facility Name
Mayo Center for Women's Health
City
Scottsdale
State/Province
Arizona
ZIP/Postal Code
85259
Country
United States
Facility Name
Northern Arizona Hematology & Oncology Associates
City
Sedona
State/Province
Arizona
ZIP/Postal Code
86336
Country
United States
Facility Name
Genesis Cancer Center
City
Hot Springs
State/Province
Arkansas
ZIP/Postal Code
71913
Country
United States
Facility Name
University of Arkansas for Medical Sciences
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Facility Name
Yanagihara, Ronald H.
City
Gilroy
State/Province
California
ZIP/Postal Code
95020
Country
United States
Facility Name
California Cancer Care, Inc.
City
Greenbrae
State/Province
California
ZIP/Postal Code
94904
Country
United States
Facility Name
University of California - San Diego/ Moores Cancer Center
City
La Jolla
State/Province
California
ZIP/Postal Code
92093-0987
Country
United States
Facility Name
LAC & USC Women's & Children's Hospital
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
Gynecologic Oncology associates
City
Newport Beach
State/Province
California
ZIP/Postal Code
92663
Country
United States
Facility Name
UC Davis Cancer Center
City
Sacramento
State/Province
California
ZIP/Postal Code
95817
Country
United States
Facility Name
California Pacific Medical Center Research Institute
City
San Francisco
State/Province
California
ZIP/Postal Code
94115
Country
United States
Facility Name
Anschutz Cancer Pavilion
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Facility Name
Anschutz Cancer Pavilion - Clinical Investigations Core
City
Aurora
State/Province
Colorado
ZIP/Postal Code
90045
Country
United States
Facility Name
University Of Colorado Health Sciences Center
City
Denver
State/Province
Colorado
ZIP/Postal Code
80262
Country
United States
Facility Name
Yale University School of Medicine
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06520
Country
United States
Facility Name
Christiana Gynecologic Oncology, LLC
City
Newark
State/Province
Delaware
ZIP/Postal Code
19713
Country
United States
Facility Name
Washington Hospital Center/Medstar Research Institute
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20010-2931
Country
United States
Facility Name
Florida Gynecologic Oncology
City
Fort Myers
State/Province
Florida
ZIP/Postal Code
33901
Country
United States
Facility Name
Miami Cancer Center at Mercy Hospital
City
Miami
State/Province
Florida
ZIP/Postal Code
33133
Country
United States
Facility Name
Miami Cancer Center at University Hospital
City
Miami
State/Province
Florida
ZIP/Postal Code
33133
Country
United States
Facility Name
University of Miami
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
Facility Name
Mt. Sinai Medical Center
City
Miami
State/Province
Florida
ZIP/Postal Code
33143
Country
United States
Facility Name
Advanced Medical Specialties
City
Miami
State/Province
Florida
ZIP/Postal Code
33176
Country
United States
Facility Name
Ocala Oncology Center
City
Ocala
State/Province
Florida
ZIP/Postal Code
34471
Country
United States
Facility Name
MD Anderson Cancer Center of Orlando
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Facility Name
Oncology & Hematology Associates of West Broward
City
Tamarac
State/Province
Florida
ZIP/Postal Code
33321
Country
United States
Facility Name
Xelero Medical Research/Giselle Ghurani
City
Tampa
State/Province
Florida
ZIP/Postal Code
33607
Country
United States
Facility Name
Medical College of Georgia
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30912
Country
United States
Facility Name
Memorial Health University Medical Center
City
Savannah
State/Province
Georgia
ZIP/Postal Code
31404
Country
United States
Facility Name
Kapiolani Medical Center for Women and Children/Univ. of HI
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96826
Country
United States
Facility Name
Northwest Memorial Hospital
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60611
Country
United States
Facility Name
Rush University Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
Cancer Institute of Central Illinois/Decatur Memorial Hospital
City
Decatur
State/Province
Illinois
ZIP/Postal Code
62526
Country
United States
Facility Name
Indiana University Obstetrics
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
00144
Country
United States
Facility Name
Indiana University Cancer Center/Indiana UNiversity Melvin & Bren Simon Cancer Center
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46202
Country
United States
Facility Name
Gynecologic Oncology of Indiana/St. Francis Cancer Research Foundation
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46267
Country
United States
Facility Name
Northern Indiana Cancer Research Consortium
City
South Bend
State/Province
Indiana
ZIP/Postal Code
46617
Country
United States
Facility Name
Louisville Oncology
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Facility Name
Franklin Square Hospital Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21237
Country
United States
Facility Name
Boston University Medical Center Hospital
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02118
Country
United States
Facility Name
Providence Cancer Center
City
Southfield
State/Province
Michigan
ZIP/Postal Code
48075
Country
United States
Facility Name
Minnesota Oncology/Hematology, PA
City
Burnsville
State/Province
Minnesota
ZIP/Postal Code
55337
Country
United States
Facility Name
St. Luke's Hospital
City
Duluth
State/Province
Minnesota
ZIP/Postal Code
55805
Country
United States
Facility Name
Minnesota Oncology/Hematology, PA
City
Edina
State/Province
Minnesota
ZIP/Postal Code
55435
Country
United States
Facility Name
Minnesota Oncology/Hematology Associates of Central Illinois
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55404
Country
United States
Facility Name
University of Minnesota
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55455
Country
United States
Facility Name
Metro-MN CCOP
City
Saint Louis Park
State/Province
Minnesota
ZIP/Postal Code
55416
Country
United States
Facility Name
Minnesota Oncology Hematology
City
Saint Paul
State/Province
Minnesota
ZIP/Postal Code
55102-2389
Country
United States
Facility Name
The West Clinic
City
Corinth
State/Province
Mississippi
ZIP/Postal Code
38834
Country
United States
Facility Name
The West Clinic
City
Southaven
State/Province
Mississippi
ZIP/Postal Code
38671
Country
United States
Facility Name
St. Luke's Hospital of Kansas City/St. Luke's Cancer Institute
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64111
Country
United States
Facility Name
Washington University School of Medicine
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Southeast Nebraska Oncology/Southeast Nebraska Cancer Center
City
Lincoln
State/Province
Nebraska
ZIP/Postal Code
68510
Country
United States
Facility Name
Comprehensive Cancer Centers of Nevada
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89109
Country
United States
Facility Name
Women's Cancer Center of Nevada
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89109
Country
United States
Facility Name
Dartmouth-Hitchcock Medical Center
City
Lebanon
State/Province
New Hampshire
ZIP/Postal Code
03756
Country
United States
Facility Name
Hematology and Oncology Associates of Northern New Jersey
City
Morristown
State/Province
New Jersey
ZIP/Postal Code
07962
Country
United States
Facility Name
University of Medicine and Dentistry of New Jersey/The Cancer Institute of Neew Jersey
City
New Brunswick
State/Province
New Jersey
ZIP/Postal Code
07090
Country
United States
Facility Name
New York Oncology Hematology, P.C.
City
Albany
State/Province
New York
ZIP/Postal Code
12208
Country
United States
Facility Name
Schwartz Gynecologic Oncology, PLLC
City
Babylon
State/Province
New York
ZIP/Postal Code
11702
Country
United States
Facility Name
Bellview Hospital
City
New York
State/Province
New York
ZIP/Postal Code
10016
Country
United States
Facility Name
New York University School of Medicine/NYU Cancer Institute
City
New York
State/Province
New York
ZIP/Postal Code
10016
Country
United States
Facility Name
NYU Cancer Institute
City
New York
State/Province
New York
ZIP/Postal Code
10016
Country
United States
Facility Name
St. Vincent Catholic Medical Center of New York
City
Staten Island
State/Province
New York
ZIP/Postal Code
10310
Country
United States
Facility Name
Brody School of Medicine
City
Greenville
State/Province
North Carolina
ZIP/Postal Code
27834
Country
United States
Facility Name
New Hanover Regional Medical Center/Zimmer Cancer Center
City
Wilmington
State/Province
North Carolina
ZIP/Postal Code
28401
Country
United States
Facility Name
Ohio State University Medical Center
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210-1228
Country
United States
Facility Name
Camelot Women's Cancer
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43214
Country
United States
Facility Name
The Arthur G. James Cancer Hospital
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43214
Country
United States
Facility Name
Cancer Care Associates
City
Tulsa
State/Province
Oklahoma
ZIP/Postal Code
74136
Country
United States
Facility Name
Oncology Associates of Oregon, PC/Willaimette Valley Cancer Center
City
Eugene
State/Province
Oregon
ZIP/Postal Code
97401-8122
Country
United States
Facility Name
Northwest Cancer Specialists, P.C.
City
Portland
State/Province
Oregon
ZIP/Postal Code
97227
Country
United States
Facility Name
Willamette Valley Cancer Center
City
Springfield
State/Province
Oregon
ZIP/Postal Code
97477
Country
United States
Facility Name
Medical Oncology Associates of Wyoming Valley, PC
City
Kingston
State/Province
Pennsylvania
ZIP/Postal Code
18704
Country
United States
Facility Name
Magee - Women's Hospital
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213
Country
United States
Facility Name
GYN Oncology Research/Gynecologic Oncology Research & Development, LLC
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29601
Country
United States
Facility Name
Chattanooga GYN Oncology
City
Chattanooga
State/Province
Tennessee
ZIP/Postal Code
37403
Country
United States
Facility Name
Hall and Martin MDs, PC
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37920
Country
United States
Facility Name
The West Clinic
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38104
Country
United States
Facility Name
West Clinic
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38120
Country
United States
Facility Name
Texas Oncology, P.A.
City
Austin
State/Province
Texas
ZIP/Postal Code
78731
Country
United States
Facility Name
Texas Oncology
City
Austin
State/Province
Texas
ZIP/Postal Code
78745
Country
United States
Facility Name
Texas Oncology, P.A.
City
Bedford
State/Province
Texas
ZIP/Postal Code
76022
Country
United States
Facility Name
Texas Oncology, P.A.
City
Dallas
State/Province
Texas
ZIP/Postal Code
75231
Country
United States
Facility Name
Sammons Cancer Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
Texas Oncology, P.A.
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
Texas Oncology, P.A.
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Facility Name
Oncology Consultants P.A.
City
Houston
State/Province
Texas
ZIP/Postal Code
77024
Country
United States
Facility Name
Cancer Care Center of South Texas
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Waco Cancer Care & Research Center
City
Waco
State/Province
Texas
ZIP/Postal Code
76712
Country
United States
Facility Name
Utah Cancer Specialists
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84106
Country
United States
Facility Name
Fletcher Allen Health Care
City
Burlington
State/Province
Vermont
ZIP/Postal Code
05401
Country
United States
Facility Name
Cancer Outreach Associates
City
Abingdon
State/Province
Virginia
ZIP/Postal Code
24211
Country
United States
Facility Name
Northern Virginia Pelvic Surgery Associates
City
Annandale
State/Province
Virginia
ZIP/Postal Code
22003
Country
United States
Facility Name
Virginia Oncology Associates
City
Newport News
State/Province
Virginia
ZIP/Postal Code
23606
Country
United States
Facility Name
Virginia Oncology Associates
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23502
Country
United States
Facility Name
Virginia Commonwealth University/VCU Massey Cancer Center
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23298
Country
United States
Facility Name
Gersh, Robert
City
Spokane
State/Province
Washington
ZIP/Postal Code
99202
Country
United States
Facility Name
Northwest Cancer Specialists, P.C.
City
Vancouver
State/Province
Washington
ZIP/Postal Code
98664
Country
United States
Facility Name
Northwest Cancer Specialists
City
Vancouver
State/Province
Washington
ZIP/Postal Code
98664
Country
United States
Facility Name
Yakima Valley Memorial Hospital
City
Yakima
State/Province
Washington
ZIP/Postal Code
98902
Country
United States
Facility Name
Aurora Medical Gyn Group
City
West Allis
State/Province
Wisconsin
ZIP/Postal Code
53227
Country
United States
Facility Name
Novartis Investigative Site
City
Adelaide
Country
Australia
Facility Name
Novartis Investigative Site
City
Herston
Country
Australia
Facility Name
Novartis Investigative Site
City
Nedlands, WA
Country
Australia
Facility Name
Novartis Investigative Site
City
South Brisbane
Country
Australia
Facility Name
Novartis Investigative Site
City
St. Leonards
Country
Australia
Facility Name
Novartis Investigative Site
City
Wodonga
Country
Australia
Facility Name
BC Cancer Agency
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 4E6
Country
Canada
Facility Name
Novartis Investigative Site
City
Calgary
Country
Canada
Facility Name
Novartis Investigative Site
City
Montreal
Country
Canada
Facility Name
Novartis Investigative Site
City
North York
Country
Canada
Facility Name
Novartis Investigative Site
City
Quebec
Country
Canada
Facility Name
Novartis Investigative Site
City
Sherbrooke
Country
Canada
Facility Name
Novartis Investigative Site
City
Toronto
ZIP/Postal Code
M5G 2M9
Country
Canada
Facility Name
Novartis Investigative Site
City
Odense
Country
Denmark
Facility Name
Novartis Investigative Site
City
Vejle
Country
Denmark
Facility Name
Novartis Investigative Site
City
Helsinki
Country
Finland
Facility Name
Novartis Investigative Site
City
Kuopio
Country
Finland
Facility Name
Novartis Investigative Site
City
Tampere
Country
Finland
Facility Name
Novartis Investigative Site
City
Amboise
Country
France
Facility Name
Novartis Investigative Site
City
Bordeaux
Country
France
Facility Name
Novartis Investigative Site
City
Caen Cedex
Country
France
Facility Name
Novartis Investigative Site
City
Herblain Cedec
Country
France
Facility Name
Novartis Investigative Site
City
Villejuif Cedex
Country
France
Facility Name
Novartis Investigative Site
City
Athens
Country
Greece
Facility Name
Novartis Investigative Site
City
Bologna
Country
Italy
Facility Name
Novartis Investigative Site
City
Milano
Country
Italy
Facility Name
Novartis Investigative Site
City
Modena
Country
Italy
Facility Name
Novartis Investigative Site
City
Monza
Country
Italy
Facility Name
Novartis Investigative Site
City
Padova
Country
Italy
Facility Name
Novartis Investigative Site
City
Roma
Country
Italy
Facility Name
Novartis Investigative Site
City
Torino
Country
Italy
Facility Name
Novartis Investigative Site
City
Krakow
Country
Poland
Facility Name
Novartis Investigative Site
City
Cape Town
Country
South Africa
Facility Name
Novartis Investigative Site
City
Johannesburg, Gauteng
Country
South Africa
Facility Name
Novartis Investigative Site
City
Klerksdorp
Country
South Africa
Facility Name
Novartis Investigative Site
City
Port Elizabeth
Country
South Africa
Facility Name
Novartis Investigative Site
City
Pretoria, Gauteng
Country
South Africa
Facility Name
Novartis Investigative Site
City
Pretoria, Guateng
Country
South Africa
Facility Name
Novartis Investigative Site
City
Sandton, Gauteng
Country
South Africa
Facility Name
Novartis Investigative Site
City
Barcelona
Country
Spain
Facility Name
Novartis Investigative Site
City
Madrid
Country
Spain
Facility Name
Novartis Investigative Site
City
Glasgow
Country
United Kingdom
Facility Name
Novartis Investigative Site
City
London
Country
United Kingdom
Facility Name
Novartis Investigative Site
City
Wirral
Country
United Kingdom
Facility Name
Novartis Investigative Site
City
Wolverhampton
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
22987083
Citation
Colombo N, Kutarska E, Dimopoulos M, Bae DS, Rzepka-Gorska I, Bidzinski M, Scambia G, Engelholm SA, Joly F, Weber D, El-Hashimy M, Li J, Souami F, Wing P, Engelholm S, Bamias A, Schwartz P. Randomized, open-label, phase III study comparing patupilone (EPO906) with pegylated liposomal doxorubicin in platinum-refractory or -resistant patients with recurrent epithelial ovarian, primary fallopian tube, or primary peritoneal cancer. J Clin Oncol. 2012 Nov 1;30(31):3841-7. doi: 10.1200/JCO.2011.38.8082. Epub 2012 Sep 17.
Results Reference
derived
Links:
URL
http://www.clinicaltrials.gov
Description
In the search box enter NCT00262990
URL
http://www.novartisclinicaltrials.com
Description
Select "Ovarian Cancer"
URL
https://www.novctrd.com/ctrdweb/trialresult/trialresults/pdf?trialResultId=3944
Description
Results for CEPO906A2303 from the Novartis Clinical Trials website

Learn more about this trial

Patupilone Versus Doxorubicin in Patients With Ovarian, Primary Fallopian, or Peritoneal Cancer

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