Combination Chemotherapy and Radiation Therapy in Treating Patients With Recurrent Metastatic Colorectal Cancer
Colorectal Cancer
About this trial
This is an interventional treatment trial for Colorectal Cancer focused on measuring adenocarcinoma of the colon, adenocarcinoma of the rectum, stage IV colon cancer, stage III colon cancer, stage III rectal cancer, stage IV rectal cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed adenocarcinoma of the colon or rectum Metastatic disease isolated to the following lymph nodes: Aortic Interaortic Celiomesenteric Retroperitoneal, including the following sites: Peri-uretal Liver Iliac Clavicle Mediastinum Inguinal Cervical Incompletely resected disease Recurrent disease, defined by 1 of the following criteria: Progression occurred within 6 months after prior oxaliplatin or after the patient received no prior oxaliplatin Progressive disease after cisplatin or fluorouracil Must be able to be encompassed in radiation field PATIENT CHARACTERISTICS: ECOG performance status (PS) 0-2 or Karnofsky PS 60-100% Life expectancy more than 12 weeks Absolute neutrophil count ≥ 1,500/mm^3 Platelet count ≥ 100,000 /mm^3 Alkaline phosphatase ≤ 5 times normal Bilirubin ≤ 2 times normal Creatinine < 2 times normal or creatinine clearance ≥ 40 mL/min No peripheral neuropathy > grade 1 Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No weight loss > 15% since diagnosis of recurrent disease No uncontrolled heart disease No angina No symptomatic disease of the inferior artery No psychological, familial, sociological, or geographical condition that would preclude study treatment or compliance PRIOR CONCURRENT THERAPY: See Disease Characteristics No prior chemotherapy or radiotherapy No concurrent corticosteroids
Sites / Locations
- Institut Sainte Catherine
- Centre Hospitalier Regional de Besancon - Hopital Jean Minjoz
- Hopital Drevon
- Hopital Robert Boulin
- Polyclinique des Quatre Pavillons
- Hopital Europeen Georges Pompidou
- Hopital Tenon
- Polyclinique De Courlancy
- C.H. Senlis