Back to resultsEnhancement of Postocclusive Reactive Hyperaemia by Dipyridamole
Primary Purpose
Hyperemia, Hypoxia
Status
Completed
Phase
Not Applicable
Locations
Netherlands
Study Type
Interventional
Intervention
dipyridamole
caffeine
Sponsored by
About this trial
This is an interventional basic science trial for Hyperemia focused on measuring adenosine, caffeine, dipyridamole
Eligibility Criteria
Inclusion Criteria: healthy volunteers between 18 and 50 years Exclusion Criteria: none specified
Sites / Locations
- Radboud university Nijmegen Medical Centre
Outcomes
Primary Outcome Measures
forearm blood flow
Secondary Outcome Measures
Full Information
NCT ID
NCT00268554
First Posted
December 21, 2005
Last Updated
March 27, 2008
Sponsor
Radboud University Medical Center
1. Study Identification
Unique Protocol Identification Number
NCT00268554
Brief Title
Enhancement of Postocclusive Reactive Hyperaemia by Dipyridamole
Official Title
Enhancement of Postocclusive Reactive Hyperaemia
Study Type
Interventional
2. Study Status
Record Verification Date
March 2008
Overall Recruitment Status
Completed
Study Start Date
December 2005 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
July 2006 (Actual)
3. Sponsor/Collaborators
Name of the Sponsor
Radboud University Medical Center
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The purpose of this study is to determine whether dipyridamole enhances postocclusive reactive hyperaemia by increasing extracellular adenosine concentrations during ischemia and reperfusion. Furthermore we hypothesize that dipyridamole augments postocclusive reactive hyperaemia by increasing adenosine receptor stimulation.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Hyperemia, Hypoxia
Keywords
adenosine, caffeine, dipyridamole
7. Study Design
Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
12 (Anticipated)
8. Arms, Groups, and Interventions
Intervention Type
Drug
Intervention Name(s)
dipyridamole
Intervention Type
Drug
Intervention Name(s)
caffeine
Primary Outcome Measure Information:
Title
forearm blood flow
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
50 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
healthy volunteers between 18 and 50 years
Exclusion Criteria:
none specified
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Gerard Rongen, MD,PhD
Organizational Affiliation
Radboud University Medical Center
Official's Role
Principal Investigator
Facility Information:
Facility Name
Radboud university Nijmegen Medical Centre
City
Nijmegen
State/Province
Gelderland
ZIP/Postal Code
6533 ZA
Country
Netherlands
12. IPD Sharing Statement
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Enhancement of Postocclusive Reactive Hyperaemia by Dipyridamole
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