Spironolactone to Decrease Potassium Wasting in Hypercalciurics on Thiazides Diuretics
Idiopathic Hypercalciuria, Hypokalemia Caused by Thiazide Diuretics
About this trial
This is an interventional treatment trial for Idiopathic Hypercalciuria focused on measuring nephrolithiasis, hypercalciuria, hypokalemia, thiazide diuretics
Eligibility Criteria
Inclusion Criteria: Age 18-65 History of idiopathic hypercalciuria (>200mg per 24 hours or a Ca/cr ratio of >140) felt to be the primary etiology of patient's kidney stones History of at least three kidney stone events On same dose of thiazide diuretic for at least three months On stable dose of K 60mEq or more a day to maintain serum K >3.5 or unable to tolerate an increase in K supplement with dose at least 40mEq a day Exclusion Criteria: Use of ACE inhibitor, ACE receptor blocker or other medication known to effect serum potassium levels GFR <80 by MDRD equation Serious cardiac disease, diabetes, CKD , current or planned pregnancy or breastfeeding History of hypertension
Sites / Locations
- Indiana University Department of Medicine, Division of Nephrology