Irinotecan in Treating Patients With Newly Diagnosed Ewing's Sarcoma
Sarcoma
About this trial
This is an interventional treatment trial for Sarcoma focused on measuring metastatic Ewing sarcoma/peripheral primitive neuroectodermal tumor
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed Ewing's tumor Ewing's sarcoma or peripheral primitive neuroectodermal tumor of bone or soft tissue High-risk disease (R3), defined as metastases at extrapulmonary/pleural sites Newly diagnosed disease Measurable primary and/or metastatic disease At least one bidimensionally measurable lesion Concurrent enrollment on EURO-Ewing99 clinical trial required PATIENT CHARACTERISTICS: No abnormal cardiac function, including any of the following: Fractional shortening < 29% Ejection fraction < 40% Glomerular filtration rate ≥ 60mL/min Not pregnant Negative pregnancy test Fertile patients must use effective contraception during and for 3 months after completion of study treatment No prior or current history of chronic diarrhea, bowel obstruction, sub obstruction, Crohn's disease, or ulcerative colitis No other medical, psychiatric, or social condition incompatible with the study treatment PRIOR CONCURRENT THERAPY: No prior chemotherapy No more than 45 days since prior definitive biopsy
Sites / Locations
- Our Lady's Hospital for Sick Children Crumlin
- Birmingham Children's Hospital
- Institute of Child Health at University of Bristol
- Addenbrooke's Hospital
- Leeds Cancer Centre at St. James's University Hospital
- Leicester Royal Infirmary
- Royal Liverpool Children's Hospital, Alder Hey
- Royal London Hospital
- Great Ormond Street Hospital for Children
- Royal Manchester Children's Hospital
- Sir James Spence Institute of Child Health at Royal Victoria Infirmary
- Queen's Medical Centre
- Oxford Radcliffe Hospital
- Children's Hospital - Sheffield
- Southampton General Hospital
- Royal Marsden - Surrey
- Royal Belfast Hospital for Sick Children
- Royal Aberdeen Children's Hospital
- Royal Hospital for Sick Children
- Royal Hospital for Sick Children
- Childrens Hospital for Wales