Memory Improvement With Docosahexaenoic Acid Study (MIDAS) (MIDAS)

Inclusion Criteria: Males or females, aged 55 or greater. Have a subjective memory complaint and have a Logical Memory subtest (of the Wechsler Memory Scale - III [WMS-III]) raw score one standard deviation or greater below the mean of a younger population. Have the ability to understand the requirements of the study; be willing to provide written informed consent; and agree to abide by the study restrictions and return for the required assessments. If taking non-prohibited medication, be on a stable drug regimen (in prior 3 months). Exclusion Criteria: Have a screening Mini-Mental State Examination (MMSE) < 26. Consume greater than 200 mg/day DHA as assessed on a DHA Food Frequency Questionnaire in the prior 2 months to screening. Use nutritional fish oil, flaxseed oil, omega-3 supplements, or huperzine in the prior 2 months to screening. Use acetylcholinesterase inhibitors or memantine in the prior 2 months to screening. Use major anti-psychotics or major anti-depressants. Use lipase inhibitors such as Xenical® (orlistat). History of major medical conditions including ischemic stroke, head trauma with loss of consciousness, epilepsy, psychosis, vascular dementia, depression (Geriatric Depression [15-item] > 5), myocardial infarction (within 1 year), uncontrolled diabetes, or blindness. History of major surgery within the past 6 months. Current use or history of drug and/or alcohol abuse within 5 years. Administration of any investigational product within the past 30 days. Inability to swallow capsules.