Gemcitabine and Docetaxel in Treating Patients With Recurrent Stage III or Stage IV Non-Small Cell Lung Cancer
Lung Cancer

About this trial
This is an interventional treatment trial for Lung Cancer focused on measuring stage IIIB non-small cell lung cancer, stage IV non-small cell lung cancer, adenocarcinoma of the lung, bronchoalveolar cell lung cancer, large cell lung cancer, recurrent non-small cell lung cancer, squamous cell lung cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed stage IIIB or IV non-small cell lung cancer, including any of the following types: Squamous cell carcinoma Adenocarcinoma, including bronchoalveolar cell adenocarcinoma Large cell anaplastic carcinoma, including giant and clear cell carcinomas Histologic or cytologic documentation of recurrence is required Measurable or evaluable disease, defined as any mass reproducibly measurable in 2 perpendicular diameters by physical examination or imaging The following lesions are not considered measurable or evaluable: Bone disease only Pleural or pericardial effusions Previously irradiated lesions, unless subsequent progression is documented CNS metastases allowed provided the patient undergoes at least 2 weeks of radiotherapy prior to study entry PATIENT CHARACTERISTICS: Not pregnant or nursing Fertile patients must use effective contraception Negative pregnancy test CALGB performance status ≤ 1 Life expectancy ≥ 3 months Granulocyte count > 1,500/mm^3 Platelet count ≥ 100,000/mm^3 Creatinine ≤ 2 times normal Bilirubin normal SGOT and/or SGPT ≤ 2.5 times upper limit of normal (ULN) AND alkaline phosphatase ≤ 1.5 times ULN OR Alkaline phosphatase 4 times ULN and SGOT and/or SGPT normal Ejection fraction normal by ECHO or MUGA No history of congestive heart failure No psychiatric illness that would preclude study compliance No serious medical or psychiatric illness that would preclude giving informed consent or limit survival to < 3 months No active uncontrolled bacterial, fungal, or viral infection No other malignancy within the past 5 years except curatively treated carcinoma in situ of the cervix or breast, basal cell or squamous carcinoma of the skin, or other surgically resected non-recurrent primary tumor not treated with adjuvant radiotherapy or chemotherapy No pre-existing peripheral neuropathy ≥ grade 2 PRIOR CONCURRENT THERAPY: At least 2 weeks since prior major surgery and recovered from acute effects At least 2 weeks since prior palliative radiotherapy and recovered from acute toxic effects Any persistent toxicity (e.g., alopecia or hyperpigmentation) not associated with clinical morbidity allowed No prior chemotherapy No concurrent cranial or thoracic radiation therapy No concurrent cytotoxic or hormonal therapy Concurrent palliative radiotherapy allowed for relief of localized pain and obstruction